objective neuromuscular characteristics in down syndrome result in generalized muscular hypotonia, developmental delays and sensory integration deficits. the aim of this study was to compare the effects of simultaneous sensory stimulations and current occupational therapy approaches on motor functions development of infants with down syndrome. materials & methods eighteen infants with down synd...

background the prevalence of celiac disease (cd) is remarkably varied in down syndrome(ds)patientscompared with other diseases.  this study aimed to assess celiac disease prevalence in down syndrome children with and without congenital heart defects (chd) and its comparison with controls. materials and methods this case-control study was performed at a single center on 132 participants in three...

objectives: one of the most effective methods to describe speech disorders is the measurement of speech intelligibility. the speech intelligibility indicates the extent of acoustic signals that correctly speaker produces and hearer receives. the purpose of this study was to investigate the speech intelligibility in the persian children with down syndrome, age range was 3 to 5 years, who had spo...

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disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (bhmt) coding gene, leads to decrease in s-adenosyl methionine (sam) synthesis which takes part in dna methylation as a methyl donor. as a result, it can promote hypo-methylation of dna, chromosome instability, and chromosome missegregation, which in turn is one of t...

down syndrome (ds), trisomy 21, is the most common chromosomal syndrome that affects one in 600-800 live births. the advanced maternal age is the only well known risk factor to cause ds. our study revealed that many young mothers produced ds children than advanced age mothers in india. a total of 150 suspected ds cases were investigated cytogenetically. randomly selected 200 healthy families in...

the purpose of the present study is the comparison of the pattern of language perception in down syndrome (ds) children and typical children. to achieve the objective, nine subjects with ds (whose mental ages were 72-78 months and were drawn from five center of special education in the city of mashhad) and five typical children with the same mental ages were selected through random sampling; an...

objectives: reading is a language skill based on visual modality which recently is addressed as a facilitator of expressive language in children with down syndrome. the aim was designing a whole word reading protocol and examining its effects on the language skills of children with down syndrome. methods: a whole word reading protocol was developed and was examined through a single-subject stud...

objectives: the aim of the study was to determine the effect of a selected exercise training on reducing symptoms of dementia caused by alzheimer's disease in people with down syndrome. methods: 27 men with down syndrome were randomized to intervention (n=13) and control (n=13) groups. all persons in experimental group followed 12 weeks selected exercise training, three times a week. prior...

objectives: the development of social skills, especially skills in relating to peers, is an important capacity that provides the foundations for lifelong success. some children with disabilities need to learn social skills more directly. the purpose of this study was to determine the effects of social skills training on socialization skills development in children with down syndrome. methods: t...