1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) alone, and in combination with N-hydroxysuccinimide (NHS) or sulfoNHS were employed for crosslinking anti-human fetuin A (HFA) antibodies on 3-aminopropyltriethoxysilane (APTES)-functionalized surface plasmon resonance (SPR) gold chip and 96-well microtiter plate. The SPR immunoassay and sandwich enzyme linked immunosorbent immunoassay (ELISA...

Endocrine disrupting chemicals (EDC) are ubiquitous and persistent compounds that have the capacity to interfere with normal endocrine homoeostasis. The female reproductive tract is exquisitely sensitive to the action of sex steroids, and oestrogens play a key role in normal reproductive function. Malignancies of the female reproductive tract are the fourth most common cancer in women, with end...

Challenges Training of site staff on EDC systems is essential to ensure data quality and returns are maximised. Guidance notes are issued to support standardised completion of case report forms. However, due to the technical nature of EDC, guidance notes alone provide insufficient support for most site staff. Provision of effective, consistent and timely EDC training across a trial’s lifespan i...

Additional Acknowledgements Magnetic resonance imaging work was performed at the Northwestern University Center for Advanced Molecular Imaging generously supported by NCI CCSG P30 CA060553 awarded to the Robert H Lurie Comprehensive Cancer Center. Metal analysis was performed at the Northwestern University Quantitative Bioelemental Imaging Center generously supported by NASA Ames Research Cente...

OBJECTIVE The food contaminants bisphenol A (BPA), diethylhexylphthalate (DEHP), and tributyltin (TBT) are potent endocrine-disrupting compounds (EDC) known to interfere with adipogenesis. EDC usually act in mixtures and not as single compounds. The aim of this study was to investigate the effects of a simultaneous exposure of BPA, DEHP, and TBT on mesenchymal stem cell differentiation into adi...

background:the aim of this study was to investigate the education board of mashhad university of medical sciences on the edo and edc, and their awareness of, attitude towards, and satisfaction with these centers. methods: in this descriptive study, all the members of the education board of mashhad university of medical sciences in the basic and clinical departments were taken as the target grou...

BACKGROUND Experimental evidence indicates that fetal exposure to xenobiotics with the potential to interfere with the endogenous steroid hormone regulation of fetal development may reduce birth weight. However, epidemiological studies are limited. The aim of the study was to investigate whether potential occupational exposure to endocrine disrupting chemicals (EDC) of the mother during pregnan...

Wireless sensor network (WSN) comprises of nodes that are spatially distributed to monitor the environments and detect the events accordingly. Correlated Data Gathering (CDG) in wireless sensor network used Adaptive and Distributed Routing (ADR) algorithm for correlated data gathering in order to minimize the total energy consumption. Though energy consumption was reduced in the network, energy...

A sequential injection analysis (SIA) using a specific condensation reaction between malonic acid and ethylenediamine with 1–(3–dimethylaminopropyl)–3–ethylcarbodiimide hydrochloride (EDC・HCl) in aqueous media was developed for EDC・HCl determination. EDC・HCl can act as a dehydration or condensation reagent for the formation of amide (peptide). The proposed system, whose operation was fully auto...

Mammalian polyamine transporters have not thus far been biochemically characterized. Since essential carboxy groups in the polyamine carrier might participate in the transport process, the ability of two different carbodi-imides to affect [3H]spermidine uptake was assessed in Chinese hamster ovary cells. Both the hydrophobic 1,3-dicyclohexylcarbodi-imide (DCC) and the more polar 1-ethyl-3-(3-di...