Although the etiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function because the endothelium regulates vessel tone and synthesizes many pro- and anti-inflammatory factors. The aim of this study was to investigate the evidence involving the endothelium in the development of varicose vein disease. In addition, tissue remodeling was invest...

Chronic venous disease is the most common vascular condition to affect the lower limb. It covers a wide range of conditions which can be broadly categorised as varicose veins, chronic venous insufficiency and venous ulcers. Venous disease is associated with a large burden of ill-health and it consumes a substantial amount of NHS resources. In the UK each year roughly half a million people consu...

Under normal circumstances, blood collected from superficial venous capillaries is directed upward and inward via one-way valves into superficial veins. These in turn drain via perforator veins, which pass through muscle fascia into deeper veins buried under the fascia. Leakage in a valve causes retrograde flow back into the vein. Unlike deep veins which are thick-walled and confined by fascia,...

From January 1987 through December 1989, ten patients with varicose veins complicated by postphlebitic ulcers were treated at Muhimbili Medical Center, Tanzania, by subfascial ligation of perforating veins. The technique employed was a posterior subfascial approach which avoids making the skin incision through the ulcer itself. The follow up periods ranged from one to three years and there was ...

Objective: To assess the long-term results of re-do surgery for recurrent varicose veins using polytetrafluoroethylene patch interposition to correct a recurrent varico-femoral junction (RVFJ). Methods: In 170 extremities (137 patients) with RVFJ greater than 3 mm in diameter, re-do surgery was done with patch interposition and without extensive resection of neovascularisation. Follow-up data b...

OBJECTIVE To develop a valid and reliable outcome measure for patients with varicose veins. DESIGN Postal questionnaire survey of patients with varicose veins. SETTING Surgical outpatient departments and training general practices in Grampian region. SUBJECTS 373 patients, 287 of whom had just been referred to hospital for their varicose veins and 86 who had just consulted a general pract...

STUDY OBJECTIVE To assess the prevalence and the extent of treatment of varicose veins in a Finnish population. DESIGN A prevalence study in a defined cohort was performed by using a mailed questionnaire. The method's validity was tested in a random sample of 166 individuals who were studied clinically. SUBJECTS In 1989 a questionnaire was mailed to every resident born in 1929, 1939, and 19...

Aims: Extracellular matrix remodeling has been implicated in a number of vascular conditions, including venous hypertension and varicose veins. However, to date no systematic analysis of matrix remodeling in human veins has been performed. Methods and Results: To understand the consequences of venous hypertension, normal and varicose veins were evaluated using proteomics approaches targeting th...

OBJECTIVES To establish the status of the deep veins in patients presenting with recurrent varicose veins and the effect on treatment decisions. DESIGN Retrospective clinical series. MATERIALS AND METHODS Duplex examination of 570 consecutive patients (843 limbs) presenting with recurrent varicose veins (CEAP C2-4). RESULTS Approximately one third of these patients (34.8%:294 limbs) had n...