Abstract Thrombotic, vascular, and bleeding complications are the most common causes of morbidity mortality in Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs). In these disorders, circulating red cells, leukocytes, platelets, as well some vascular endothelial each have abnormalities that cell-intrinsic to MPN driver mutations they harbor (eg, JAK2 V617F). When cells activat...

Regenerative Vascular Tissue Engineering In article number 2200050, Quinton Smith and co-workers review strategies for regenerative vascular tissue engineering. The vasculature is a conduit that links various organ systems, guiding development, homeostasis, regeneration. They reflect in this cover the ability of cells (green endothelial cells) to self-assemble interact with parenchymal (red, st...

Leaf Veins The leaf vein is the “vascular system” in plants. In article 2201220 by Kelvin W. K. Yeung, Xin Zhao, and co-workers, a leaf-vein micropattern engraved on PGLADMA polymer membrane, serving as “running tracks” for vascular endothelial cells to facilitate hierarchical functional reconstruction. membrane can induce cell differentiation, vasculature reconstruction, vessel maturation.

background: beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in so...

Background: Beta-adrenergic blocking agents have been broadly used for treatment of many cardiovascular diseases such as arterial hypertension and ischemic heart failure. Anti-tumoral, anti-inflammatory and anti-angiogenesis effects of propranolol (a non-selective beta-adrenergic blocker) have been shown. Angiogenesis (replenish of the pre-existing vascular networks) plays a critical role in s...

The relationship between sickle cell disease (SCD), hearing and cognitive impairment is intertwined due to the vaso-occlusive, vascular insults tissue hypoxia associated with disease.

In articule number 2001706 by Georgia Papavasiliou and co-workers, vascular cell-laden gradient PEG hydrogels with five types of combinations including immobilized cell adhesion peptide concentration (RGD), stiffness, protease-sensitivity are designed to investigate their role on spatial variations in sprouting responses 3D culture.