Abstract Background In silico studies further provided predictive binding properties of selected ligands for inhibition target protein. the study, molecular poses Cucurbitacin-E and antioxidant enzymes (glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), peroxidase (GPx) acetylcholinesterase (AChE) Galleria mellonella were determined in silic...

Background and objectives: Ecballium elaterium (L.) A. Rich (squirting cucumber) has been used traditionally as a remedy for different disorders such as fever, sinusitis, and rheumatic disease. In the present study, antibacterial, antioxidant, and cytotoxic activities of leaves and fruits were evaluated. Also, total flavonoid and phenolic contents were measured were me...

Despite recent advances in antibiotic therapy, sepsis remains a major clinical challenge in intensive care units. Here we examined the anti-inflammatory and antioxidant effects of Ecballium elaterium (EE) on brain, and explored its therapeutic potential in an animal model of sepsis-associated encephalopathy (SAE) [induced by cecal ligation and puncture (CLP)]. Thirty rats were divided into thre...

Introduction: Cucurbitacins are highly oxygenated compounds abundantly found in Cucurbitaceous genera such as Citrullus, Cucumis, Cucurbita and Luffa (11). A relatively common cucurbitacin found in Cucurbitaceous species is cucurbitacin E (CuE). Although cucurbitacins exhibit positive effects both pharmacologically (1-3, 6, 14, 17) and in protecting the plants from certain diseases (5), they ha...