Platinum-based chemotherapies such as cisplatin are used as first-line treatment for many cancers. Although there is often a high initial responsiveness, the majority of patients eventually relapse with platinum-resistant disease. For example, a subset of testicular cancer patients still die even though testicular cancer is considered a paradigm of cisplatin-sensitive solid tumors, but the mech...

BACKGROUND Estrogen replacement attenuates the increased risk of cardiovascular disease in postmenopausal women. Recent studies using an in vitro culture system have shown that estrogen inhibits endothelial cell (EC) apoptosis. The in vivo relevance of this finding, however, is not defined. To do so, we have developed a rat vascular injury model in which EC apoptosis induced by hydrogen peroxid...

Non-linear video editing was for several years a domain for professionals due to high prices of capture devices and cameras and difficult to use video manipulation software. With the broad availability of cheap video capture and recording devices video editing became popular also in the consumer market. However, software for manipulating digital video is still complicated to use for home users ...

For agent-based systems to reach their full potential, an important capability for individual agents is adaptation. An adaptive technique that is particularly well suited to the agent-based paradigm is provided by evolutionary computation (EC). EC systems have been shown to develop complex groups of coevolved structures. In fact, Holland’s original vision of artificial adaptive systems was more...

In a natural environment, avoidance of a particular food source is mostly determined by a previous intake experience during which sensory stimuli such as food odor, become aversive through a simple associative conditioned learning. Conditioned odor aversion learning (COA) is a food conditioning paradigm that results from the association between a tasteless scented solution (conditioned stimulus...