It is well known that maternal ageing not only causes increased spontaneous abortion and reduced fertility, but it is also a high genetic disease risk. Although assisted reproductive technologies (ARTs) have been widely used to treat infertility, the overall success is still low. The main reasons for age-related changes include reduced follicle number, compromised oocyte quality especially aneu...

Advances in the diagnosis and treatment of cancer have resulted in a growing population of adolescent and adult long-term survivors of malignancies with infertility problems due to induced premature ovarian failure. Although several options are currently available to preserve fertility in cancer patients, cryopreservation of ovarian tissue is the only option available for prepubertal girls and ...

Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications. Its relevance has increased in recent years due to the fact that age of motherhood is being delayed in developed countries, with the risk of having either primary ovar...

The primordial follicle assembly, activation and the subsequent development are critical processes for female reproduction. A limited number of primordial follicles are activated to enter the growing follicle pool each wave, and the primordial follicle pool progressively diminishes over a woman's life-time. The number of remaining primordial follicles represents the ovarian reserve. Identificat...

The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’. This aphorism was returned to publicity lately when Peter Nilsson reintroduced the concept of early vascular ageing. As vascular ageing is described a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modificat...

Ovarian tumour therapy has been known to cause ovary ageing. The competitive endogenous RNA (ceRNA) network plays an indispensable role in various diseases. We constructed the ceRNA examine of circular (circRNA) ovaries older women and elucidate intervention mechanism Ziyin Buyang Formula. tissue datasets were obtained from Gene Expression Omnibus (GEO) database screened for differentially expr...

BACKGROUND Depletion of ovarian follicles is associated with the end of reproductive function in ageing females. Recently, it has been described that this process parallels increases in the concentration of norepinephrine (NE) in the rat ovary. In sexually mature rats, experimentally-induced increases in the sympathetic tone of the ovary is causally related to ovarian cyst formation and derange...

Initiation of growth of resting ovarian follicles is a key phenomenon for providing an adequate number of mature oocytes in each ovulation, while preventing premature exhaustion of primordial follicle reserve during the reproductive lifespan. Resting follicle dynamics strongly suggest that primordial follicles are under constant inhibitory influences, by mechanisms and factors whose nature rema...

background: detection of best predictor of ovarian reserve in patients with temporarily or consistently elevated early follicular phase serum levels of fsh is one of the most important goals in assisted reproductive technique (art). objective: to evaluate whether high level of anti-mullerian hormone level is related to success of art in patients with temporarily or consistently elevated early f...