The structure of the title compound, C11H7NO2, is isotypic to that of its homologue, 1-octylindoline-2,3-dione [Qachchachi et al. (2013 ▶). Acta Cryst. E69, o1801]. The indoline ring and the two carbonyl O atoms are approximately coplanar, the largest deviation from the mean plane being 0.021 (1) Å for one of the O atoms. The mean plane through the fused ring system is nearly perpendicular to t...

The title salt, C8H12NO(+)·Br(-)·H2O, is isomorphous with the chloride analogue [Seethalakshmi et al. (2013). Acta Cryst. E69, o835-o836]. In the solid state, the cations, anions and water mol-ecules are inter-linked by a network of O-H⋯O, O-H⋯Br and C-H⋯Br inter-actions. The water mol-ecule makes two O-H⋯Br hydrogen bonds, generating [010] zigzag chains of alternating water mol-ecules and brom...

The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape...

In the mononuclear title complex, [Co(N3)2(C12H8N4S)2], the cobalt(II) atom is located on an inversion centre and displays an axially weakly compressed octa-hedral coordination geometry. The equatorial positions are occupied by the N atoms of two 2,5-bis-(pyridin-2-yl)-1,3,4-thia-diazole ligands, whereas the axial positions are occupied by N atoms of the azide anions. The thia-diazole and pyrid...

Redetermination of the crystal structure of N-(β-carb-oxy-eth-yl)-α-isoleucine, C9H18N2O3, reported earlier by Nehls et al. [Acta Cryst. (2013), E69, o172-o173], was undertaken in which the ionization state assigned to the mol-ecule as unionized has been modified as zwitterionic in the present work. Single-crystal X-ray intensity data obtained from freshly grown crystals and freely refining the...

1. Rezvani I, Rezvani GA. An approach to inborn errors of metabolism. In: Kliegman R, Stanton B, St Geme JW, Schor NF, Behrman RE, editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: W.B. Saunders Company; 2016. p. 634‐6. 2. Burton BK. Inborn errors of metabolism in infancy: A guide to diagnosis. Pediatrics 1998;102:E69. 3. Sperling MA. Hypoglycemia. In: Kliegman R, Stanton B, St Gem...

We read with great interest the article by Glaser and Shah titled “Root Cause Analysis of Paraplegia Following Transforaminal Epidural Steroid Injections: The Unsafe Triangle (Pain Physician 2010; 13:237-244). For years, the well known “safe triangle” (when performing transforaminal lumbar epidural steroid injection) has been taught and learned by hundreds of interventionists in International S...

Surface expression of the group 1 K30 capsular polysaccharide of Escherichia coli strain E69 (O9a:K30) requires Wza(K30), a member of the outer membrane auxiliary (OMA) protein family. A mutation in wza(K30) severely restricts the formation of the K30 capsular structure on the cell surface, but does not interfere with the biosynthesis or polymerization of the K30 repeat unit. Here we show that ...

The relationship between financial development and economic growth is the crucial issues which could grab economists and policy makers' attention to it. Financial market plays an essential role on each economy, because it conducts funds to those individuals or firms which have productive investment opportunities. If the financial system does not perform this role efficiently, the economic effic...