Cancer sequencing studies are increasingly comprehensive and well powered, returning long lists of somatic mutations that can be difficult to sort and interpret. Diligent analysis and quality control can require multiple computational tools of distinct utility and producing disparate output, creating additional challenges for the investigator. The Cancer-Related Analysis of Variants Toolkit (CR...

We investigated hydrothermal liquefaction of Nannochloropsis sp. at different temperatures (250e400 C), times (10e90 min), water densities (0.3e0.5 g/mL), and biomass loadings (5 e35 wt %). Liquefaction produced a biocrude with light and heavy fractions, along with gaseous, aqueous, and solid by-product fractions. The gravimetric yields of the product fractions from experiments at 250 C summed ...

aCGH: array comparative genomic hybridization FFPE: formalin-fixed paraffin-embedded MCC: Merkel cell carcinoma MCpV: Merkel cell polyomavirus PET/CT: positron emission tomography/ computed tomography SLNB: sentinel lymph node biopsy INTRODUCTION In the United States, the incidence and mortality rates for Merkel cell carcinoma (MCC) have more than tripled in the last 2 decades. The main risk fa...

Genome-wide expression data from tumors and cell lines in breast cancer, together with drug response of cell lines, open prospects for integrative analyses that can lead to better personalized therapy. Drug responses and expression data collected from cell lines and tumors were used to generate tripartite networks connecting clusters of patients to cell lines and cell lines to drugs, to connect...

OBJECTIVES/HYPOTHESIS Mesenchymal stem cells (MSCs) hold therapeutic promise for vocal fold scar, yet the precise mechanism(s) underlying tissue level changes remain unclear. We hypothesize that MSCs interact with native fibroblasts to favorably affect healing. Furthermore, we hypothesize that these interactions vary based on MSC source. METHODS Vocal fold fibroblasts (VFFs), adipose-derived ...

Cell lineage analysis in rodents has shown that the cerebral cortex is formed from both widespread and large radial clustered clones representing partly distinct lineages and producing differing cell types. Since previous cell lineage analysis of the ferret cortex using retroviral libraries showed that most neurons labeled at E33-E35 formed widespread clones, we determined whether clones labele...

The emergence of multi drug resistant pathogens such as Methicillin Staphylococcus aureus (MRSA) has become a threat to public health. Thus, the development new antibiotics global concern. Many scientists are attracted towards discovery antimicrobial agents from microbial sources. aim this study is isolate potential Bacillus species soil for production substance. During study, 20 samples were c...

Aql X-1 is a soft X-ray transient source and emits type I X-ray bursts. A spectral state transition was observed with RXTE during its outburst decay in February and March 1997. Its 10-30 keV and 5-10 keV count rate ratio increased suddenly when its luminosity was between (4-12) E35 ergs/s, assuming a 2.5 kpc distance. Spectral fitting with a model composed of a blackbody and a power-law compone...