نتایج جستجو برای: e3

تعداد نتایج: 11331  

Journal: :The EMBO journal 2007
Stjepan Uldrijan Willem-Jan Pannekoek Karen H Vousden

MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for degradation. The RING domain is essential for the E3 activity of MDM2, and we show here that the extreme C-terminal tail of MDM2 is also critical for efficient E3 activity. Loss of E3 function in MDM2 mutants deleted of the C-terminal tail correlated with a failure of these mutants to oligomerize with MDM2, o...

Journal: :The Biochemical journal 1996
A Kikonyogo R Pietruszko

Enzyme purification and characterization, cDNA cloning and Northern blot analysis were the techniques utilized during this investigation to determine the identity and occurrence of the aldehyde dehydrogenase that metabolizes gamma-aminobutyraldehyde in adult human brain. The purification yielded one major protein which was active with gamma-aminobutyraldehyde. It had the physico-chemical and ki...

Journal: :Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 2010
F Demet Arslan Ince Ayşenur Atay Mehmet Köseoğlu Murat Yeşil Erdal Deveci

OBJECTIVE To explore the possible contribution of the apolipoprotein (apo) E polymorphisms to the extent and severity of coronary artery disease (CAD) related to lipid metabolism. METHODS Overall, 53 Turkish patients, aged 54+/-11 years defined by coronary angiography were included in this cross-sectional study. Reardon's coronary artery scoring was used. Serum lipids were measured with enzym...

Journal: :Molecular medicine reports 2016
Jian Ding Bao-Ting Zhu

The present study aimed to investigate the dose-dependent modulating effect of estriol (E3), an estrogen predominantly produced during human pregnancy, on antigen‑induced production of specific antibodies in female BALB/c mice. The animals were immunized either with bovine serum albumin (BSA) or the pneumococcal polysaccharide serotype-14 (PPS-14), and the levels of specific serum antibodies we...

2010
JOSEPH MARTIN

It is the goal of this note to show that each disk in E3 contains a tame arc which intersects the boundary of D. In [l ] Bing shows that each disk in E3 contains many tame arcs. The reason that the arguments given in [l ] do not show that each disk contains a tame arc intersecting the boundary is that a disk in E3 need not lie on a closed surface in E3 [7]. This difficulty can be overcome using...

The way Energy, Economy and Environment systems correlate along with the appropriate policy will bring about a countries sustainable growth and economic development (E3 Models). The models deals with the relation between these aspects are generalized versions of economic growth models which take into account the energy and environmental factors. This research analyses concurrent efffect of ene...

Journal: :The Journal of biological chemistry 2011
Jie Fu Lenong Li Marlene Bouvier

Our understanding of the mechanism by which the E3-19K protein from adenovirus (Ad) targets major histocompatibility complex (MHC) class I molecules for retention in the endoplasmic reticulum is derived largely from studies of Ad serotype 2 (subgroup C). It is not well understood to what extent observations on the Ad2 E3-19K/MHC I association can be generalized to E3-19K proteins of other serot...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2002
Kaori Suzuki Ramón Alemany Masato Yamamoto David T Curiel

PURPOSE The initial development of conditionally replicative adenoviruses (CRAds) for cancer treatment has aimed at achieving selective replication in and killing of malignant cells. Other aspects such as the potentiation of the cytolytic capacity have also been investigated but still require new endeavors. As an extension of our prior work, we analyzed the effect of the E3 region, which includ...

Journal: :Human molecular genetics 1996
Y S Hong D S Kerr W J Craigen J Tan Y Pan M Lusk M S Patel

An infant girl with elevated blood lactate, pyruvate, and plasma branched-chain amino acids was diagnosed with dihydrolipoamide dehydrogenase (E3; dihydrolipoamide: NAD+ oxidoreductase, EC 1.8.1.4) deficiency. Activities of the pyruvate dehydrogenase complex and E3 from patient were 26 and 2% of controls in blood lymphocytes, and 11 and 14% in cultured skin fibroblasts, respectively. Western bl...

ژورنال: :علوم زراعی ایران 0
یوسف ارشد بخش تحقیقات ژنتیک بانک ژن گیاهی ملی ایران مهدی زهراوی بخش تحقیقات ژنتیک بانک ژن گیاهی ملی ایران

ترجیح دادن مواد اصلاحی پیشرفته از سوی به نژادگران در جهت تسریع در تولید ارقام جدید اصلاحی باعث برانگیخته شدن نگرانی جهانی از محدود شدن پایه ژنتیکی ارقام گیاهی گردیده است و این موضوع در تقابل با تنوع ژنتیکی گسترده ای است که در بانک های ژن موجود می باشد، بنابراین شناسایی ژنوتیپ های بومی واجد خصوصیات مفید از ارزش زیادی برخوردار است. در این آزمایش 17 ژنوتیپ بومی از کلکسیون گندم بانک ژن گیاهی ملی ای...

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