The aim of this study is to evaluate the effectiveness Dydrogesterone in PPOS protocols for IVF/ICSI cycles or Oocyte cryopreservation both blocking LH surge as well number metaphase II oocytes. 550 plus 186 oocyte from January 2018 December 2020, no age restriction. All patients were given Follitropin delta (Rekovelle®, Ferring Pharmaceuticals) Menotropin (Menopur®, a fixed daily SC dose. Clin...

17 beta-Estradiol (E2) exerts negative feedback effects at the hypothalamo-pituitary level on serum FSH. This study investigated the effects of repeated daily administration of intranasal E2 (S21400) on the pharmacokinetics (PK) of E2 and estrone (E1) and the pharmacodynamics (PD) of FSH and assessed the PK/PD relationship between E2 and FSH using population model-dependent analysis. Postmenopa...

For many years it has been perceived wisdom that hormone replacement therapy for women with a uterus should include a progestin to prevent the proliferative effects of estrogen on the endometrium and endometrial cancer. But, with the reports from the Women's Health Initiative (WHI) and Million Women Study indicating that such regimens are associated with an increased risk of breast cancer, wher...

Micronized progesterone and dydrogesterone have a similar partial effect pattern, which does not induce unwanted effects, when used in pregnancy. Also their major actions regarding implantation, preparation of the endometrium, blood flow increase, spiral artery development, uterine quiescence, cervical rigidity and protection of the semi-allogenic fetus not to be attacked by the maternal immune...