OBJECTIVE To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. MATERIALS AND METHODS The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subj...

In this study, we used invasive tracing to evaluate white matter tractography methods based on ex vivo diffusion-weighted magnetic resonance imaging (dwMRI) data. A representative selection of tractography methods were compared to manganese tracing on a voxel-wise basis, and a more qualitative assessment examined whether, and to what extent, certain fiber tracts and gray matter targets were rea...

The complex array of fiber orientations exhibited by muscles such as the tongue, esophagus, and heart, enable function beyond basic pulling. Among other things, the presence of crossing geometry adds the ability to push by bi-directional contraction causing expansion in the orthogonal direction. Diffusion weighted magnetic resonance imaging (DW-MRI), provides a convenient, non-destructive, meth...

Introduction: Diffusion Weighted Magnetic Resonance Imaging (DWMRI) provides visual contrast, depends on Brownian motion of water molecules. The diffusive behavior of water in cells alters in many disease states. Dephasing is a factor of magnetic field inhomogeneity, heterogeneity of tissue and etc., which is associated with the signal amplitude. In a series of DWI acquisition...

Nuclear spin hyperpolarization can dramatically increase the sensitivity of the C magnetic resonance experiment, allowing dynamic measurements of the metabolism of hyperpolarized C-labeled substrates in vivo. Here, we report a preclinical study of the response of lymphoma tumors to the vascular disrupting agent (VDA), combretastatin-A4-phosphate (CA4P), as detected by measuring changes in tumor...

Substantial effort is being expended on using micro-structural modeling of the white matter, with the goal of relating diffusion weighted magnetic resonance imaging (DWMRI) to the underlying structure of the tissue, such as axonal density. However, one of the important parameters affecting diffusion is the water exchange rate between the intra- and extra-axonal space, which has not been fully i...

OBJECTIVE To investigate a correlation between preoperative non-echo planar diffusion-weighted magnetic resonance imaging (non-EPI DW MRI) with surgical findings of localization and extension of cholesteatoma and to develop criteria for surgical planning. PATIENTS Preoperative non-EPI DWMRI was available and positive for cholesteatoma in 27 patients with primary and 23 with residual/recurrent...