نتایج جستجو برای: dutp

تعداد نتایج: 3480  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
B K Tye P O Nyman I R Lehman S Hochhauser B Weiss

Strains of Escherichia coli with a mutation in the sof (dnaS) locus show a higher than normal frequency of recombination (are hyper rec) and incorporate label into short (4-5S) DNA fragments following brief [3H]thymidine pulses [Konrad and Lehman, Proc. Natl. Acad. Sci. USA 72, 2150 (1975)]. These mutant strains have now been found to be defective in deoxyuridinetriphosphate diphosphohydrolase ...

Journal: :Journal of immunology 2010
Benjamin Roche Aurélie Claës François Rougeon

Somatic hypermutation (SHM) of Ig genes is the result of a two-phase process initiated by activation-induced cytidine deaminase, relying on two different strategies for the introduction of mutations at CG pairs (phase I) and at AT pairs (phase II). To explain the selectivity of phase II, two mechanisms were proposed: AT-selective error-prone DNA-polymerases, deoxyuridine triphosphate (dUTP) inc...

Journal: :Cytogenetic and genome research 2009
S Müller M Cremer M Neusser F Grasser T Cremer

Quantum dots (Qdots) are semiconductor nanocrystals, which are photo-stable, show bright fluorescence with narrow, symmetric emission spectra and are available in multiple resolvable colors. We established a FISH protocol for the simultaneous visualization of up to 6 different DNA probes differentially labeled with Qdots and with conventional organic fluorochromes. Using a Leica SP5 laser scann...

2017
Anna Hagenkort Cynthia B.J. Paulin Matthieu Desroses Antonio Sarno Elisée Wiita Oliver Mortusewicz Tobias Koolmeister Olga Loseva Ann-Sofie Jemth Ingrid Almlöf Evert Homan Thomas Lundbäck Anna-Lena Gustavsson Martin Scobie Thomas Helleday

The antimetabolite 5-Fluorouracil (5-FU) is used in the treatment of various forms of cancer and has a complex mode of action. Despite 6 decades in clinical application the contribution of 5-FdUTP and dUTP [(5-F)dUTP] and 5-FUTP misincorporation into DNA and RNA respectively, for 5-FU-induced toxicity is still under debate.This study investigates DNA replication defects induced by 5-FU treatmen...

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