Background: The neuroprotective effects of duloxetine, as an antidepressant agent, and the neurodegenerative effects of methamphetamine have been shown in previous studies. Nonetheless, their exact neurochemical and behavioral effects are still unclear. In the current study, we sought to clarify the molecular mechanisms involved in the protective effects of duloxetine against methamphetamine-in...

Duloxetine is a potent and balanced dual inhibitor of serotonin and norepinephrine reuptake being investigated for the treatment of depression and urinary incontinence. The disposition of duloxetine was studied in four healthy human subjects after a single 20.2-mg (100.6 microCi) oral dose of [14C]duloxetine in an enteric-coated tablet. The mean total recovery of radioactivity (+/- S.E.M.) afte...

conclusions this preliminary assessment suggests that duloxetine may be a medication of interest in the treatment of children with adhd. further controlled studies with larger samples are required to evaluate the efficacy of duloxetine in treatment of children with adhd. results ten children with a mean age of 8.40 ± 1.67 years terminated the trial. a significant reduction in cprs-r and its sub...

Understanding the effect of characteristics formulation and process parameters on physicochemical properties a pharmaceutical product is very significant for development solid dosage forms, as knowledge gained small scale batches in early phase used later phases lifecycle or other products. One approaches gaining better understanding effects production quality finished to apply systematical app...