We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42 lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal, 53 lobular, 14 in situ with ductal and lobular features) by immunohistochemistry. We found a highly significant correlation of E-cadherin membrane expression with the histologic phenotype of the tumors. While moder...

Several studies have reported that pancreatic ductal preservation greatly improved the islet yield and function after cold storage. However, these studies were devoid of appropriate controls, such as vascular perfusion, which is routinely performed to preserve organs in the clinical setting. In this study, we created a vascular perfusion model using inbred rats, and investigated the effect of d...

background and objective: nonsteroidal anti-inflammatory agents are the treatment of choice for ductal closure in premature newborn. this study evaluates early and late outcome, as well as the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus (pda) in premature infants. methods: in this clinical trial, all preterm infants below 37 weeks, with documentation of pda were...

in human breast cancer, estrogen receptor (er) status of the tumor has prognostic and therapeutic significance. however, facilities to study er are not widely available to us. we postulated that if there is a correlation between histologic grade and er status of invasive ductal carcinoma (idc), it may help predict the er status of the tumor. of 8 4 cases of breast carcinoma referred to the canc...

malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. however, association of apocrine metaplasia in papilloma with ductal carcinoma in situ (dcis) is not very well defined. the lesions with apocrine metaplasia are not only di...

INTRODUCTION: The architecture of the ductal trees was first investigated by Sir Astley Cooper in 1840, using duct injection studies ex-vivo (1). Recently, computer derived tracking of whole-breast ductal trees has been achieved in few human breasts using mastectomy specimens (2). Studying the architecture of the entire ductal trees is very challenging and has not been achieved in vivo, yet (3,...

BACKGROUND Invasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets. RESULTS The total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enr...

Ductal carcinoma in situ (DCIS) is a breast (BC) consisting of malignant cells the ductal lumen without invasion beyond epithelial membrane. The article presents rare clinical case combined course chronic mastitis and 47-year-old female patient who was diagnosed with during instrumental examination, only after trepan biopsy subsequent histological intraductal cancer verified. This may indicate ...

BACKGROUND To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic. METHODS In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and ...

Numerous studies have evaluated the association between factors related to maturation and reproduction and breast cancer risk, but few have assessed how these factors are related to different histologic types of breast cancer among postmenopausal women. We used polytomous logistic regression to assess the effect of age at maximum height and reproductive factors on risk of invasive breast cancer...