The RNA-guided Cas9 system is a versatile tool for genome editing. Here, we established a RNA-guided endonuclease (RGEN) system as an in vivo desired-target mutator (DTM) in maize to reduce the linkage drag during breeding procedure, using the LIGULELESS1 (LG1) locus as a proof-of-concept. Our system showed 51.5%-91.2% mutation frequency in T0 transgenic plants. We then crossed the T1 plants st...

Discrete-time modeling (DTM) dominates the systems engineering literature in the applications of block-oriented modeling. The discrete environment of computer-based process control systems and discrete sampling are the two major reasons [1]. Also, a DTM is easier to obtain because all input changes are approximated by piecewise step input sequences. Nonetheless, DTM has (potentially) two critic...

As the number of cores in multicore processors and their operating frequency continue to grow, processor power consumption increases and leads to an escalation in chip temperatures. This escalation causes today’s multicore processors’ performance to be limited by chip thermal constraints rather than process technology or circuit design. As a result, Dynamic Thermal Management (DTM) has an incre...

PURPOSE To evaluate in-office dermatophyte test medium (DTM) culture as an alternative to traditional laboratory fungal culture for confirming a diagnosis of onychomycosis, and to determine the prevalence of dermatophytes as a cause of onychomycosis in patients not participating in a clinical trial. DESIGN This nationwide multicenter prospective study enrolled 1100 adult patients with suspect...

Thermal-aware design of disk-drives is important because high temperatures can cause reliability problems. Dynamic thermal management (DTM) techniques have been proposed to operate the disk at the average case temperature, rather than at the worst case by modulating the activities to avoid thermal emergencies caused by unexpected events, such as fan-breaks, increased inlet air temperature, etc....

OBJECTIVE To evaluate the performance of the in-office dermatophyte test medium (DTM) culture when used to confirm the diagnosis of onychomycosis in diabetic patients. RESEARCH DESIGN AND METHODS Nail samples from 184 diabetic patients who exhibited symptoms consistent with toenail onychomycosis were screened for dermatophyte fungal infection using DTM, potassium hydroxide evaluation, and cen...

Dermatophyte test media (DTM) and Sabouraud's dextrose agar (SDA) are well established media for recovery of dermatophytes from clinical samples of dermatophytosis. Skin, hair and nail samples were mycologically examined from 112 patients attending Outpatient Clinic of Dermatology and Veneriology in Mansoura University Hospital in an attempt to compare dermatophyte identification media (DIM) wi...

This study focuses on the automatic extraction of DTMs from urban DEMs produced by image correlation. Many methods have been proposed in the literature yet processing correlation DEMs in any kind of areas remains a challenge. This paper presents a hybrid approach that combines complementary aspects of both TIN-based and segmentation-based techniques. Unlike previous work involving two complemen...

Network-Enabled Servers (NES) environments are valuable candidates to provide simple computing grid access. These environments allow transparent access to a set of computational servers via Remote Procedure Call mechanisms. In this context, a challenge is to increase performances by decreasing data traffic. This paper presents DTM (Data Tree Manager) a data management service for NES environmen...