Ultraviolet irradiation (UV) exposure constitutes the most relevant environmental hazard to human skin. UV-mediated cutaneous inflammation and direct DNA damage lead promotion of skin carcinogenesis. D-dopachrome tautomerase (D-DT), a functional homolog macrophage migration inhibitory factor (MIF), has similarities MIF. However, its role, unlike role MIF in photocarcinogenesis, is unknown. We t...

to determine the usefulness of the time intervals obtained from the first derivative of apex cardiogram (da/dt) in assessing contraction and relaxation, 20 hemodynamically and angiographical1y investigated patients with coronary artery disease and 29 patients with hypertensive heart disease were studied. as a control group there were used 50 normal subjects. since contraction and relaxation is ...

In this article we study the existence of periodic solutions of the second order nonlinear neutral differential equation with functional delay d dt x (t) + p (t) d dt x (t) + q (t) x (t) = d dt g (t, x (t− τ (t))) + f ` t, x (t) , x (t− τ (t)) ́ . The main tool employed here is the Burton-Krasnoselskii’s hybrid fixed point theorem dealing with a sum of two mappings, one is a large contraction an...

The tumor suppressor p53 is induced by genotoxic stress in both normal and transformed cells and serves to transcriptionally coordinate cell cycle checkpoint control and programmed cell death responses. Macrophage migration inhibitory factor (MIF) is an autocrine and paracrine acting cytokine/growth factor that promotes lung adenocarcinoma cell motility, anchorage-independence and neo-angiogeni...

This study describes a method for performing diffusivity measures along and across a specific direction, derived from white matter in healthy controls. The diffusion tensor (DT) assigns a principal eigenvector (v₁) and eigenvalue (axial diffusivity, d(ax)) to each voxel. The average of the second and third eigenvalues is the radial diffusivity, d(rad) v₁ may be affected by pathology, therefore ...

Let D be a pseudoconvex domain in Ckt × C n z and let φ be a plurisubharmonic function in D. For each t we consider the ndimensional slice of D, Dt = {z; (t, z) ∈ D}, let φ be the restriction of φ to Dt and denote by Kt(z, ζ) the Bergman kernel of Dt with the weight function φ. Generalizing a recent result of Maitani and Yamaguchi (corresponding to n = 1 and φ = 0) we prove that logKt(z, z) is ...

This study aimed to explore the effect of DT-13 (25(R,S)-ruscogenin- 1-O- [β-d-glucopyranosyl- (1→2)][β-d-xylopyranosyl-(1→3)]-β -d- fucopyranoside) on tumor necrosis factor (TNF)-α-induced vascular inflammation and the potential molecular mechanisms. In vitro, DT-13 suppressed TNF-α-induced adhesion and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting the expression o...

This paper explains how radio frequency (RF) background noise produces uncertainty in measured diffusion tensor MRI (DT-MRI) data, how this noise can be modeled, and how its effects can be mitigated. DT-MRI data are derived from a series of magnitude diffusion-weighted images (DWI) in which RF noise is rectified. A new Gaussian distribution is proposed that describes the variability of the esti...

We establish two fixed-point theorems for mappings satisfying a general contrac-tive inequality of integral type. These results substantially extend the theorem of Branciari (2002). In a recent paper [1], Branciari established the following theorem. Theorem 1. Let (X, d) be a complete metric space, c ∈ [0, 1), f : X → X a mapping such that, for each x, y ∈ X, d(f x,f y) 0 ϕ(t)dt ≤ c d(x,y) 0 ϕ(...