نتایج جستجو برای: dsrna virus
تعداد نتایج: 399148 فیلتر نتایج به سال:
Transgenic plants expressing double-stranded RNA (dsRNA) of virus origin have been previously shown to confer resistance to virus infections through the highly conserved RNA-targeting process termed RNA silencing or RNA interference (RNAi). In this study we applied this strategy to soybean plants and achieved robust resistance to multiple viruses with a single dsRNA-expressing transgene. Unlike...
A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers formation of signaling complexes called inflammasomes. These then initiate pyroptosis, a highly inflammatory form cell death. Recent work has shown that rhinovirus protease can activate human NLRP1 inflammasome, but it was unclear whether this is ...
Betanodavirus B2 belongs to a group of functionally related proteins from the sense-strand RNA virus family Nodaviridae that suppress cellular RNA interference. The B2 proteins of insect alphanodaviruses block RNA interference by binding to double-stranded RNA (dsRNA), thus preventing Dicer-mediated cleavage and the subsequent generation of short interfering RNAs. We show here that the fish bet...
Endornaviruses have large double-stranded RNA (dsRNA) genomes that carry a single open reading frame (ORF). Here we report the complete genome of a novel endornavirus, assembled from next-generation sequence data generated from Vitis vinifera-extracted dsRNA. Two different fungal hosts have been identified for this virus, suggesting that horizontal transmission of the virus is possible.
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport intern...
A research project was conducted to detect presence of mycovirus, a probable virocontrol agent in Sclerotium rolfsii, destructive soil-borne plant pathogenic fungus. total 500 isolates the pathogen isolated from infected wheat, bush bean, tomato, eggplant, lentil, chickpea, chilli and okra grown Bangladesh following tissue planting methods brought Virology laboratory Okayama University, Japan. ...
Crude extracts of bacterially expressed dsRNA can be used to protect plants against virus infections
BACKGROUND Double-stranded RNA (dsRNA) is a potent initiator of gene silencing in a diverse group of organisms that includes plants, Caenorhabditis elegans, Drosophila and mammals. We have previously shown and patented that mechanical inoculation of in vitro-transcribed dsRNA derived from viral sequences specifically prevents virus infection in plants. The approach required the in vitro synthes...
Filoviruses, including Marburg virus (MARV) and Ebola virus (EBOV), cause fatal hemorrhagic fever in humans and non-human primates. All filoviruses encode a unique multi-functional protein termed VP35. The C-terminal double-stranded (ds)RNA-binding domain (RBD) of VP35 has been implicated in interferon antagonism and immune evasion. Crystal structures of the VP35 RBD from two ebolaviruses have ...
The influenza A virus nonstructural NS1 protein is known to modulate host cell gene expression and to inhibit double-stranded RNA (dsRNA)-mediated antiviral responses. Here we identify NS1 as the first viral protein that antagonizes virus- and dsRNA-induced activation of the stress response-signaling pathway mediated through Jun N-terminal kinase.
Double-stranded (ds)RNA is an important nonspecific indicator of the presence of RNA viruses in bacteria, fungi and plants (1,3). The dsRNA usually represents either the replicative form or the genome of an RNA virus, or it may be an intermediate in the replication of viroids or satellite RNAs. Its size(s) can provide specific information on the likely identity of a virus-like agent infecting a...
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