Cancer cells demand high ATP provisions to support proliferation, and targeting of energy metabolism is a good strategy to increase their sensitivity to treatments. In Brazil, wine manufacture is expanding, increasing the amount of pomace that is produced. We determined the phenolic composition and antioxidant properties of a dark skin Grape Pomace Extract and its effects on metabolism and redo...

The adverse effect of cypermethrin on the liver and kidney of weanling female rats and the protective effect of ethanolic extract of grape pomace were investigated in the present study. Weanling female rats were given cypermethrin oral at a dose of 25 mg kg(-1) body weight for 28 consecutive days. An additional two Cyp-trated groups received extract at a dose of 100 and 200 mg kg(-1) body weigh...

Synergy could be an effective strategy to potentiate and recover antibiotics nowadays useless in clinical treatments against multi-resistant bacteria. In this study, synergic interactions between antibiotics and grape pomace extract that contains high concentration of phenolic compounds were evaluated by the checkerboard method in clinical isolates of Staphylococcus aureus and Escherichia coli....

Abstract Phenolic compounds and biopotential (antioxidant, cellular antioxidant cytotoxic activity) of grape pomace (GP) skin, seed, stem whole GP originating from indigenous red variety Prokupac were evaluated. The UHPLC-Orbitrap MS4 analysis showed the presence 75 phenolic (57 non-anthocyanins 18 anthocyanins), among which considerable content ethyl gallate was observed malvidin-3-O-hexoside-...

Grape pomace (pulp and skins) was investigated as a new biosorbent for removing mycotoxins from liquid media. In vitro adsorption experiments showed that the pomace obtained from Primitivo grapes is able to sequester rapidly and simultaneously different mycotoxins. Aflatoxin B1 (AFB1) was the most adsorbed mycotoxin followed by zearalenone (ZEA), ochratoxin A (OTA), and fumonisin B1 (FB1), wher...

Because of the growing interest in nutraceuticals and their health benefits, it is important to develop tools for modeling degradation of nutraceuticals in low-moistureand high-temperature-heated foods. The objective of this study was to estimate the kinetic parameters for the degradation of anthocyanins in grape pomace and to calculate the bootstrap confidence interval (CI), which is a more re...

Abstract Grape pomace, as by-product of wine making, is a source polyphenols, fibers, fatty acids, metals, and organic which could be used raw component for the production sustainable materials. Novel biodegradable films based on pomaces, from Negroamaro (red) Fiano (white), Italian grape cultivars, were fabricated. Physical, chemical antioxidant properties material produced characterized. In p...

Diabetes mellitus is a group of metabolic syndromes with a hallmark of hyperglycemia. Serious long-term complications from diabetes are a major cause of hospitalization and death. We recently discovered that grape pomace, the by-product from the waste of the wine and juice industries, had great potential to prevent diabetes. In this study, we examined the potential use of grape pomace in contro...

Red wines and their grape pomaces are important sources of phenolic compounds. Inhibition plateletaggregation is one the mechanisms proposed for cardioprotective effect compounds fromwine pomace; however, content affected by region, variety winemaking process.In present study, antiplatelet red was related to its content(determined spectrophotometric techniques) profile (determined using HPLC-MS...

In this study phenolic compounds extraction from grape byproducts was conducted using pure water as a solvent. High temperatures and low time incubation periods were used in the aim of reducing the cost of the process and heightening the phenolic compounds yield. Response surface methodology (RSM) was realized to study the effect of time and temperature on crushed and uncrushed grape pomace. Th...