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In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320 000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multidrug-resistant strains of Mycobacterium tube...

Increasingly, poorly soluble drug candidates are entering development, which has made identifying and selecting stable solid forms of an active pharmaceutical ingredient (API) with enhanced in vivo absorption more difficult. While pharmaceutical salts are the most common choice for solid forms, cocrystals are also known to improve “druggability” characteristics such as solubility, dissolution, ...

Acinetobacter baumannii, a gram negative bacteria, has emerged as critical pathogen responsible for nosocomial and other infections. A. baumannii exhibits resistance to variety of antibiotic classes, emphasizing that new therapeutic targets are urgently needed. In ATCC 179778, 458 genes have been identified essential genes, indispensable growth survival the pathogen. The functions 47 proteins e...