Background: Blood transfusion is the main source for the spread of hepatitis C virus (HCV) and other related infections throughout the world. These infections are more common in replacement donors than in voluntary blood donors. Aims and Objectives: To evaluate various demographic and etiological factors for the transmission of HCV infection among voluntary and replacement blood donors. Materia...

BACKGROUND To date, most studies on deferral of blood donors have focused on men who have sex with men (MSM) and/or injecting drug users. Few have examined deferrable risk behaviors relating to transfusion-transmissible infections (TTIs) in general. This study aimed to examine the prevalence of, and factors associated with, nondisclosure of TTI-related risk behaviors in donors. STUDY DESIGN A...

Inflammations generate uneasiness. This study adopts quantum mechanical and molecular docking approach to model explore twenty derivatives of ibuprofen as potential non-steroidal anti-inflammatory drug candidates taking the standard. Optimization calculation drug-like chemical parameters compounds were conducted at DFT/B3LYP/6-31G* level theory. Binding affinity, interaction inhibition drug-can...

Kasuya, Morimasa (Nagoya University School of Medicine, Nagoya, Japan). Transfer of drug resistance between enteric bacteria induced in the mouse intestine. J. Bacteriol. 88:322-328. 1964.-Transfer of multiple drug resistance in the intestines of germ-free and conventional mice was studied with strains of Shigella, Escherichia, and Klebsiella. The transfer experiment was carried out under antib...

BACKGROUND In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of this case-control study was to investigate the risk factors for presence of ...

All blood donors in Scotland who were found to be infected with hepatitis C virus (HCV) in the first 6 months of routine testing of all donations for anti-HCV were contacted. Those who attended were counselled, a history of exposure to risk was sought, and blood was taken for alanine aminotransferase (ALT) level as a measure of liver function. The epidemiological features were then correlated w...

Activation of synovial fibroblasts (SFs) contributes to rheumatoid arthritis (RA) by damaging synovial membranes and generating inflammatory cytokines that recruit immune cells to the joint. In this paper we profile cytokine secretion by primary human SFs from healthy tissues and from donors with RA and show that SF activation by TNF, IL-1α, and polyinosinic-polycytidylic acid (Poly(I:C)) cause...

Introduction: Transfusion of blood and its components is a life- saving manoeuvre but has life threatening hazards as well. Blood Service (BTS) covered by “Drug Cosmetics Act” legal implications. Hence, strict criteriae are followed while selecting donor, particularly emphasising on Transmissible Infections (TTI), which may improve safe transfusion practices. Aim: To study the seroprevalence Hu...