With juices of grapefruit and related fruits, possible relationships between contents of six different furanocoumarins and extents of inhibition of microsomal CYP3A activity have been studied in vitro. Microsomal CYP3A-mediated testosterone 6beta-hydroxylation was inhibited by the addition of a fruit juice (2.5%, v/v) from eight different grapefruit sources, two sweeties, three pomelos, and one...

This study evaluated the hypothesis that untreated and irradiated grapefruit as well as the isolated citrus compounds naringin and limonin would protect against azoxymethane (AOM)-induced aberrant crypt foci (ACF) by suppressing proliferation and elevating apoptosis through anti-inflammatory activities. Male Sprague-Dawley rats (n = 100) were provided one of five diets: control (without added g...

BACKGROUND Grapefruit juice impacts the metabolism of a number of drugs via inhibition of a variety of metabolic enzymes. This study evaluated the impact of grapefruit juice on the antiplatelet activity of a loading dose and 7 days of maintenance therapy with clopidogrel. METHODS Healthy volunteers participated in two separate treatment protocols. The first protocol included a single 300 mg l...

Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Here we show that nanoparticles made of grapefruit-derived lipids, which we call grapefruit-derived nanovectors, can deliver chemotherapeutic agents, short interfering RNA, DNA expression vec...

The biology of the citrus psyllid Diaphorina citri Kuwayama was studied at 258C on four commonly grown citrus and related plants [rough lemon, Citrus jambhiri Lush; sour orange, C. aurantiumL.; grapefruit,C.paradisiMacfadyen; andorange jessamine,Murrayapaniculata(L.) Jack] in the laboratory. The biological characteristics of each life stage are described. The average egg incubation periods on o...

A new type of interaction in which fruit juices diminish oral drug bioavailability through inhibition of uptake transport is the focus of this review. The discovery was based on an opposite to anticipated finding when assessing the possibility of grapefruit juice increasing oral fexofenadine bioavailability in humans through inhibition of intestinal MDR1-mediated efflux transport. In follow-up ...

The biology of the citrus psyllid Diaphorina citri Kuwayama was studied at 25 degrees C on four commonly grown citrus and related plants [rough lemon, Citrus jambhiri Lush; sour orange, C aurantium L.; grapefruit, C. paradisi Macfadyen; and orange jessamine, Murraya paniculata (L.) Jack] in the laboratory. The biological characteristics of each life stage are described. The average egg incubati...

Sexually mature, mated female Mexican fruit ßies, Anastrepha ludens (Loew), from a laboratory culture, whether starved or not, were attracted to grapefruit in a wind tunnel. Females starved for 24 h were more strongly attracted than fed females but those starved for 48 h were equivalent to fed females in responsiveness. There were no signiÞcant differences in propensity to attempt oviposition o...

1 Identify the mechanism of grapefruit juice-drug interactions and drugs involved with significant grapefruit-drug interactions. 2 Describe potential effects of grapefruit juice-drug interactions.. 3 Discuss medications that may be affected and degree of risk associated with common interacting medications.. 4 Identify effective alternative medications that do not interact (for patients who do n...