نتایج جستجو برای: drd2
تعداد نتایج: 1180 فیلتر نتایج به سال:
Objective The current study aimed to explore the association of single nucleotide polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine receptors with schizophrenia and genetic association with risperidone treatment response. Methods A total of 690 schizophrenic patients (case group) were selected and 430 healthy people were included as the controls. All patients receiv...
Abstract Exposure to the hight-fat diet may alter control of food intake promoting hyperphagia and obesity. The objective this study was investigate effects on dopamine receptors (drd1 drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, preference in adult rats. Wistar female rats were fed a or during pregnancy lactation. offspring allocated into groups: Lactation – Control...
The possible association of the DRD2 locus, and in particular the Taql-A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither...
Dopamine (DA) signals are transmitted via specific receptors including the D2 receptors (D2R). Previous studies have shown that D2R upregulation in the nucleus accumbens (NAc) attenuated alcohol consumption. We hypothesized that upregulation of D2R in the NAc would significantly influence alcohol drinking. We tested this hypothesis by determining the effect that D2R upregulation has on alcohol ...
Objectives Regulation of pro-inflammatory factors such as TNF-α which are secreted by the immune cells through induction of their several receptors including dopamine receptors (especially DRD2 and DRD3) is one of the noticeable problems in diabetic severe foot ulcer healing. This study was conducted to evaluate the alteration of TNF-αin plasma as well as DRD2 and DRD3 changes in PBMCs of diabe...
Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2...
Chronic neuroinflammation is a common feature of aging brain and some neurodegenerative diseases, including Parkinson’s disease. However, the molecular mechanisms underlying regulation of innate immunity in the central nervous system remain elusive. Here we show that dopamine receptor D2 (Drd2), known as a critical component for dopamine neurotransmission and a susceptibility gene for Parkinson...
In view of documented evidence demonstrating the association of dopaminergic metabolism and neurotransmission with Parkinson's disease (PD), a case-control study was conducted to investigate the impact of particular polymorphisms in the catechol O-methyl transferase (COMT) H108L, monoamine oxidase B (MAOB) int 13 A>G, dopamine transporter 1 (DAT1) A1215G, dopamine receptor D2 (DRD2) Taq1A, DRD2...
Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking.
A recent study showed an association between the dopamine D2 receptor gene (DRD2) and smoking. The purpose of this study was to determine if the familial transmission of smoking is linked to variation at the DRD2 locus in a genetically informative sample. Subjects were identified in alcohol treatment centers and their relatives were recruited for study. All subjects were interviewed to assess a...
Obesity is influenced by environmental, behavioral, and genetic factors; particularly genes related to the regulation of lipids addictive behavior. Food craving (FC) a physiological behavioral response that triggers intense desire ingest food, food with high energy, fat, and/or sweet content. Objective: To evaluate relationship between prevalence FC in obese subjects blood as well determine tra...
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