Under the Human Genome Project, a rough draft of the human genome will be sequenced in 2000, and almost all in 2003. The next step is to obtain functions of the genes in the genome. Structural genomics and pharmacogenomics are among the promising approaches to elucidate them. A gene function is regarded as the protein function and thus the atomic configurations in functional sites of the protei...

The European Commission has presented a draft for an Artificial Intelligence Act (AIA). This article deals with legal and ethical questions of the datafication human emotions. In particular, it raises question how emotions are to be legally classified. concept “emotion recognition systems” in sense (AIA) published by is addressed. As turns out, fundamental right freedom thought as well common g...

AIM To document variability in the standard of skeletal surveys received for a second opinion in suspected non-accidental injury (NAI). MATERIALS AND METHODS The skeletal surveys of 50 consecutive infants and children under 2 years of age were reviewed. A simple scoring system was developed based on fulfillment of specific parameters. Each radiograph was then assigned a score reflecting its o...

various scoring systems have been devised to aid diagnosis of acute appendicitis. the main objective of this study was finding the accuracy of modified alvarado score in prediction of acute appendicitis. the registries of cases with appendectomy, who had been admitted to a referral medical center in the capital of iran from february 2000 to march 2004, were studied. sensitivity and specificity ...

The authors have carried out an investigation of the two "draft maps of the human proteome" published in 2014 in Nature. The findings include an abundance of poor spectra, low-scoring peptide-spectrum matches and incorrectly identified proteins in both these studies, highlighting clear issues with the application of false discovery rates. This noise means that the claims made by the two papers ...

Protein-based virtual screening plays an important role in modern drug discovery process. Most protein-based virtual screening experiments are carried out with docking programs. The accuracy of a docking program highly relies on the incorporated scoring function based on various energy terms. The existing scoring functions deal all the energy terms with the equal weight function or other weight...

Motivation: Many heuristic algorithms have been designed to approximate p-values of DNA motifs described by position weight matrices, for evaluating their statistical significance. They often significantly deviate from the true p-value by orders of magnitude. Exact p-value computation is needed for ranking the motifs. Furthermore, surprisingly, the complexity of the