The Dirac point (DP) with a double-cone structure for optical fields can be realized in optically homogenous media. The condition for the realization of DP in optical systems is the varying of refractive index from negative to zero and then to positive. Our analysis verify that, similar to electrons in graphene, the light field near DP possesses of the pseudodiffusive property obeying the 1/L s...

During T cell development in the thymus, pre-T cell receptor (TCR) complexes signal CD4(-) CD8(-) (double negative [DN]) thymocytes to differentiate into CD4(+) CD8(+) (double positive [DP]) thymocytes, and they generate such signals without apparent ligand engagements. Although ligand-independent signaling is unusual and might be unique to the pre-TCR, it is possible that other TCR complexes s...

Methods Thirty-six subjects with LAR to DP were selected to participate in a double-blind, placebo-controlled, parallelgroup, phase II clinical trial of subcutaneous AIT in LAR. The patients were randomized to receive AIT-DP with Pangramin PLUS, ALK, DP, or placebo for a period of 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints wer...

DP-coloring (also called correspondence coloring) is a generalization of list coloring introduced by Dvo\v{r}\'{a}k and Postle in 2015. Motivated results related to Cartesian products graphs, we initiate the study DP-chromatic number, $\chi_{DP}$, same. We show that $\chi_{DP}(G \square H) \leq \text{min}\{\chi_{DP}(G) + \text{col}(H), \chi_{DP}(H) \text{col}(G) \} - 1$ where $\text{col}(H)$ nu...

BACKGROUND Biologic disease-modifying antirheumatic drugs, including tumor necrosis factor inhibitors such as etanercept (Enbrel®), have improved outcomes for patients with rheumatic and other inflammatory diseases, with sustained remission being the optimal goal for patients with rheumatoid arthritis. Flexible and convenient treatment options, compatible with modern lifestyle, are important in...

Peripheral CD4CD8 double positive (DP) T cells have been reported to play a role in several autoimmune diseases, virus infections and cancer. In rheumatoid arthritis (RA), both CD4 and CD8 single positive (SP) T cells are known to be involved in the pathogenesis, but the role of peripheral CD4CD8 DP T cells has not been investigated in detail. Anti cyclic citrullinated antibodies (ACPA) positiv...

Perspective functions have long been used to convert fractional programs into convex programs. More recently, they have been used to form tight relaxations of mixed-integer nonlinear programs with socalled indicator variables. Motivated by a practical application (maximising energy efficiency in an OFDMA system), we consider problems that have a fractional objective and indicator variables simu...

Abstract Background and Aims It is well known that oxygen transport ability impaired in patients with anemia, low hemoglobin (Hb) level, whereas the double product (DP, bpm*mmHg), consisting of systolic blood pressure (SBP) multiplied by heart rate (HR), an index myocardial consumption. The combination these two markers could be a potential marker for balance supply demand. Therefore, we hypoth...

The hemodynamic and metabolic responses to proprioceptive neuromuscular facilitation (PNF) exercise were examined in 32 male university students (aged 19-28 years). Ten repetitions of PNF exercises were applied to the subjects' dominant upper extremities in the following order: as an agonist pattern flexion, adduction and external rotation; and as an antagonist pattern extension, abduction and ...

Acute hemodynamic changes induced by two beta-blocking agents, bunitrolol and propranolol, in patients with ischemic heart disease were studied. Besides possessing negative chronotropic and inotropic effects which were demonstrated by decreased heart rate (HR), cardiac index (CI) and double product (DP) of the heart, propranolol significantly increased systemic vascular resistance (SVR, 12%, p ...