OBJECTIVE To determine if a reduction in proton radiation dose from the standard dose of 70 cobalt gray equivalents (CGE) to 50 CGE would decrease radiation-induced complications, thereby improving visual prognosis, without compromising local tumor control for patients with uveal melanoma at high risk of these complications. DESIGN Randomized, double-masked clinical trial. PARTICIPANTS A to...

Apoptosis is a highly conserved program of cell death in multicellular organisms that is central to their homeostasis. Defects in apoptosis are associated with cancer as well as neurodegenerative and autoimmune diseases. There are two ways apoptosis can be induced: intrinsic and extrinsic. The intrinsic pathway is triggered via changes in the mitochondria, the extrinsic pathway via stimulation ...

BACKGROUND Acinetobacter baumannii is an opportunistic microorganism with an increasing role in nosocomial outbreaks. For the last 2 decades, a growing number of carbapenem-resistant A. baumannii strains have been identified, including the metallo-beta-lactamases (MBLs) producers. The study aimed to investigate the genetic relatedness of, and MBLs production among, a collection of A. baumannii ...

effects of different tillage systems on dispersion ratio, status of aggregation, degree of aggregation, mean weight diameter, geometric diameter, the rain-fed wheat yield and the yield components were investigated by a field trial using a completely randomized block design with five treatments in four replicates during 2009-2010 growing season at gorgan university of agricultural science and na...

Brief strong depolarization of cerebellar Purkinje cells produces a slow inward cation current [depolarization-induced slow current (DISC)]. Previous work has shown that DISC is triggered by voltage-sensitive Ca influx in the Purkinje cell and is attenuated by blockers of vesicular loading and fusion. Here, we have sought to characterize the ion channel(s) underlying the DISC conductance. While...

Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.

We have found the first convincing evidence for spiral structure in the accretion disc of a close binary. The eclipsing dwarf nova binary IP Peg, observed during the end phase of a rise to outburst, shows strong Balmer and Helium emission lines in its spectra, with asymmetric double peaked velocity profiles produced in the accretion disc around the white dwarf. To reveal the two armed spiral on...

I model profiles of the [Ne ii] forbidden emission line at 12.81μm, emitted by photoevaporative winds from discs around young, solar-mass stars. The predicted line luminosities (∼ 10L⊙) are consistent with recent data, and the line profiles vary significantly with disc inclination. Edge-on discs show broad (30–40 km s−1) double-peaked profiles, due to the rotation of the disc, while in face-on ...

OBJECTIVES The aims of this study were to determine the prevalence of extended-spectrum beta-lactamases (ESBLs) in AmpC-carrying Enterobacter spp. in a tertiary care university hospital in Vienna, Austria, and to implement a cost-effective strategy to detect ESBLs in this particular genus on a routine basis. METHODS Clinical Enterobacter isolates (n=208) were investigated by means of (i) an i...