BACKGROUND Serotonergic raphespinal neurons and their fibers have been mapped in large mammals, but the non-serotonergic ones have not been studied, especially in the mouse. The present study aimed to investigate the termination pattern of fibers arising from the hindbrain raphe and reticular nuclei which also have serotonergic neurons by injecting the anterograde tracer BDA into them. RESULT...

We have studied the distribution of neurokinin A-like immunoreactive cell bodies and fibers in the cat brainstem. The densest clusters of perikarya containing the peptide were observed in the periaqueductal gray, inferior colliculus, postpyramidal nucleus of the raphe, medial nucleus of the solitary tract and in the lateral reticular nucleus. By contrast, the interpeduncular nucleus, magnocellu...

In the present study nicotine (0.1 mg/kg, s.c.) increased discharge rate of putative dorsal raphe (DRN) serotonergic neurons of behaving rats during REM sleep (362.61%), without any significant change during waking and non-REM sleep. Since serotonergic DRN neurons gate PGO onset, these results suggest that nicotine-induced suppression of PGO spikes during REM sleep previously reported is achiev...

The dorsal raphe nucleus was stimulated electrically and chemically in 57 cats with blood pressure being measured by an arterial catheter. Blood pressure rose by a mean of 119.5 +/- 8.9% on stimulation of the dorsal raphe nucleus at a frequency of 200 sec-1. This pressor response was frequency-dependent over the range 0.2 to 200 sec-1 and the site of origin was localized to the dorsal raphe nuc...

Alterations in the development of the serotonin system can have prolonged effects, including depression and anxiety disorders later in life. Serotonin axonal projections from the dorsal raphe undergo extensive refinement during the first 2 weeks of postnatal life in rodents (equivalent to the third trimester of human pregnancy). However, little is known about the functional properties of seroto...

(Neuron 106, 498–514.e1–e8, May 6, 2020) In the original version of this paper, representative heatmap in lower panel Figure 5B was incorrectly presented as duplicate upper panel. The online figure has been updated with correct data. This mistake does not affect any other data and analysis paper. There is no associated change to text. authors apologize for error. Raphe Dopamine System Controls ...

1. We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). 2. Alnespirone (0.1-3 mg kg(-1), s.c.) dos...

The ascending serotonergic projections are derived mainly from mesencephalic raphe nuclei. Topographical projections from mesencephalic raphe nuclei to the striatum were examined in the rat by the retrograde transport technique of HRP (horseradish peroxidase). In 29 rats stereotaxically injection of HRP enzyme were performed in dorsal and ventral parts of striatum separately. The extent of the ...