In the preceding study a, we found that the effects of cervical dorsal column (DC) lesions were revealed by neurological and roughness-discrimination tests if the lesions destroyed at least 90 ~o of the total DC cross-sectional area. Since the dorsal columns form the major spinal input to the coronal somatosensory cortex12,13,18, unit recordings from this area should reflect the effects of DC l...

Objective(s): Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is a lack of investigation of the effects of propofol on spinal dorsal horn which is important for the sensory transmission of nociceptive signal...

BACKGROUND Digital nerve block is commonly performed by care providers in medical fields. This study compares the blocks in terms of effectiveness of anesthesia and pain. METHODS Patients were divided into two groups. First group underwent digital block whereas 2nd group had transmetacarpal digital block. The subcutaneous ring block was performed by two injections of 3 ml of 2% lignoca...

Objective(s): The present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. Materials and Methods: Oxaliplatin (5 mg/kg) or saline was administered to adult male Sprague-Dawley rats.  Gabapentin (60 mg/kg, IP) or vehicle was injected daily. Mechanical allodynia was assessed us...

Background and Objective: Sensory neurons have critical role in improvement of functional outcome of any neuroprotective strategy. The herbal medicine Nepeta menthoides has been reported to have anti-apoptotic effect on axotomized spinal motoneurons. In the present study, the putative neuroprotective effect of Nepeta menthoides on the axotomized dorsal root ganglion sensory neurons in neonate r...

introduction: transcranial magnetic stimulation (tms) is a useful tool for assessment of corticospinal excitability (cse) changes in both healthy individuals and patients with brain disorders. the usefulness of tms-elicited motor evoked potentials (meps) for the assessment of cse in a clinical context depends on their intra-and inter-session reliability. this study aimed to evaluate if removal ...

a two-variable integrate and fire model is presented to study the role of transient outward potassium currents in producing temporal aspects of dorsal cochlear nucleus (dcn) pyramidal cells with different profiles namely the chopper, the pauser and the buildup. this conductance based model is a reduced version of km-lif model (meng & rinzel, 2010) which captures qualitative firing features of a...