Ovarian serous carcinoma, the most common and lethal type of ovarian cancer, is thought to develop from two distinct molecular pathways. High-grade (HG) serous carcinomas contain frequent TP53 mutations, whereas low-grade (LG) carcinomas arise from serous borderline tumors (SBT) and harbor mutations in KRAS/BRAF/ERBB2 pathway. However, the molecular alterations involved in the progression from ...

Context: The emergence of bone health maintenance in breast cancer patients is known as an indispensable aspect survival and morbidity improvement; therefore, bisphosphonates play a substantial role the prevention/delaying treatment induced loss skeletal-related events (SREs) these patients, although this drug can cause necrosis jaw. In article, we aimed at summarizing updated evidence on admin...

Objective: Patients with primary immunodeficiencies (PID) verified by clinical disease and standard immunological diagnostics but without a genetic diagnosis remain a challenge. Genetic diagnosis is important in order to plan follow-up and treatment possibilities including bone marrow transplantation and genetic counselling. Methods: We used array comparative genomic hybridization (aCGH) analys...