نتایج جستجو برای: dna polymorphism
تعداد نتایج: 593379 فیلتر نتایج به سال:
In order to determine genetic variability among 33 isolates of Fusarium semitectum, morpho- logical and molecular studies were carried out. Isolates from different paddy fields in the north of Iran were separated from each other in four morphotype groups. The isolates showed a high level of variation in aerial mycelium, color of colony, number of septa and growth rate on potato dextrose agar (P...
background the association between her2 ile655val single nucleotide polymorphism and cancer is controversial. objectives the aim of our study was to investigate this polymorphism in patients with ovarian cancer. patients and methods genomic dna was extracted from peripheral blood leukocytes of 107 patients and 130 healthy women. her2 gene polymorphism was assessed by pcr-rflp. results no signif...
Background and purpose: Colorectal cancer is one of the most common cancers in the world and Iran. This cancer is a multifactorial disease that is induced by interaction of various genetic and environmental factors. In this study, we investigated the interactions between different environmental factors and candidate polymorphisms of two genes in colorectal cancer X-ray repair cross-complementin...
Background and purpose: CYP1B1 is involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone and xenobiotic induced carcinogenesis. Polymorphisms in CYP1B1 could result in modifications in its enzyme activity and are known to be associated with cancer susceptibility related to environmental toxins and hormone exposure. Moreover, the association of CYP1B1 p...
Diabetes mellitus and obesity are very similar in terms of pathogenesis pathophysiology. Most obese patients have adipose tissue dysfunction caused by genetic environmental factors. Adipose is the source adipokines secreted from adipocytes. Vaspin, Visfatin Chemerin discovered recent years. The study consists 43 non-diabetic 51 diabetic individuals. PCR-RFLP method agarose gel electrophoresis t...
To identify cultivars quickly and accurately, DNA fingerprinting of 10 broccoli varieties was performed by using simple sequence repeat (SSR) marker technology. Highly informative polymorphic SSR markers were screened rapeseed. Out the 93 pairs, 21 pairs selected found to have good polymorphism. Each pair generated 1 bands with an average 4.29. The polymorphism information content (PIC) 0.41 a ...
A DNA polymorphism for an Xbal site in intron 22 of the human factor VIII:C gene extends the utility of DNA methods for carrier detection in families segregating for hemophilia A. While the DNA polymorphism detected by a BclI site in intron 18 of the factor VIII:C gene was informative for 41% of females studied, the BglI/intron 25 polymorphism provided no additional information because of appar...
Background and purpose: Gastric cancer is one of the most prevalent cancers with a low-five year survival rate. Some factors such as molecular pathway are associated with the development of disease and metastasis is the most important factor for death. Caspase 9 is initiator CASP of internal apoptosis pathway and have important role in cancer development. Polymorphism of CASP 9 gene promoter co...
Background: The thymidine kinase (TK) and DNA polymerase (pol) genes of herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) are important targets for genotypic determination of HSV resistance to antiviral drugs. The knowledge of gene polymorphism is an absolute requirement for the correct interpretation of genotypic findings. Methods: In this study, the natural polymorphism of TK and DNA pol...
disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (bhmt) coding gene, leads to decrease in s-adenosyl methionine (sam) synthesis which takes part in dna methylation as a methyl donor. as a result, it can promote hypo-methylation of dna, chromosome instability, and chromosome missegregation, which in turn is one of t...
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