La cystinose est une maladie rare qui résulte d'un défaut d'expression de la cystinosine transporteur de la cystine du lysosome. La forme infantile est la plus fréquente et la plus sévère. Elle conduit en dehors du traitement à l'insuffisance rénale chronique terminale au cours de la première décade de la vie. Nous rapportons l'expérience tunisienne de la cystinose infantile. Une étude rétrospe...

1. Concha M, Casares J, Ross DN, González-Lavín L, Franco M, Mesa D, et al. Reemplazamiento valvular aórtico con autoinjerto pulmonar (operación de Ross), en pacientes adultos y pediátricos. Estudio preliminar. Rev Esp Cardiol. 1999;52:113-20. 2. Rus C, Mesa D, Concha M, Casares J, Suárez de Lezo J, Delgado M, et al. Resultados a corto plazo en la técnica de Ross. ¿Influye la etiología de la va...

Nephropathy is a common diabetes complication. ERRFI1 gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in ERRFI1 gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without neph...

Objectives: Dry Needling (DN) is a novel and effective intervention for patients with Myofascial Pain Syndrome (MPS). Some characteristics, such as needle penetration depth, needle insertion into the target muscle, and trigger points must be identified in this intervention. The Ultrasound (US)-guided DN is a technique that involves needle insertion at the site of injury and the simulation of ti...

Individual indices of spectral analysis (SA) of heart rate variability (HRV), which are used to diagnose the autonomic nervous system (ANS) activity, often give somewhat inconclusive and antagonistic results. Based on the results of age dependence (Šlachta et al., 2002), and dependence of exercise intensity (Stejskal et al., 2001) on the short-term SA HRV, the authors developed a new evaluation...

1. Concha M, Casares J, Ross DN, González-Lavín L, Franco M, Mesa D, et al. Reemplazamiento valvular aórtico con autoinjerto pulmonar (operación de Ross), en pacientes adultos y pediátricos. Estudio preliminar. Rev Esp Cardiol. 1999;52:113-20. 2. Rus C, Mesa D, Concha M, Casares J, Suárez de Lezo J, Delgado M, et al. Resultados a corto plazo en la técnica de Ross. ¿Influye la etiología de la va...

Diabetic nephropathy (DN) is a well-known complication of diabetes and leading cause of chronic renal failure and end-stage renal disease (ESRD). Currently, angiotensin converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) are the standard of care for this disease although trials targeting the renin-angiotensin-aldosterone system demonstrate that they delay the progressi...

N europathy is a frequent complication of diabetes and is a major cause of morbidity and mortality, potentially affecting distal sensory, motor, and autonomic nerves. Sequelae of diabetic neuropathy (DN) include foot ulceration, which can lead to the devastating consequence of lower limb amputation. Accurate and timely detection, characterization, and quantification of DN are critical in order ...

​Background and purpose: Glycation products, oxidative stress, and inflammation contribute to the development of diabetic nephropathy (DN) due to the elevation of transforming growth factor-β1 (TGF-β1). This study aimed at investigating the effect of Cysteine (Cys) on TGF-β in DN rat model. Materials and methods: In this experimental study, 40 male Wistar rats were randomly divided into four g...