Monoamine oxidase inhibitors (MAOIs) are often ingested together with tryptamine hallucinogens, but relatively little is known about the consequences of their combined use. We have shown previously that monoamine oxidase-A (MAO-A) inhibitors alter the locomotor profile of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in rats, and enhance its interaction with 5-HT2A receptors. Th...

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT or street name "5-MEO") is a newer designer drug belonging to a group of naturally occurring indolealkylamines. Our recent study has demonstrated that coadministration of monoamine oxidase A (MAO-A) inhibitor harmaline (5 mg/kg) increases systemic exposure to 5-MeO-DMT (2 mg/kg) and active metabolite bufotenine. This study is aimed at delineating harm...

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen, acting as a non-selective serotonin 5-HT(1A)/5-HT(2A)-R agonist. Psychotomimetic agents such as the non-competitive NMDA-R antagonist phencyclidine and serotonergic hallucinogens (DOI and 5-MeO-DMT) disrupt cortical synchrony in the low frequency range (<4 Hz) in rat prefrontal cortex (PFC), an effect reversed by antipsycho...

The time course of N.N-dimethyltryptamine (DMT) levels in brain and liver of adult male Holtzman rats was determined with and without pretreatment with the monoamine oxidase inhibitors iproniazid (32 mg/kg) and tranylcypromine (IO mg/kg) given i.p. DMT was given in doses of 1.0. 3.2 and 10.0 mg/kg i.p. DMT was assayed spectrophotofluorometrically and in some Instances by a radioisotopic method....

We recently discovered an opioid peptide analgesic, 2',6'-dimethyltyrosine (Dmt)-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA), that can protect against ischemia-induced myocardial stunning. In buffer-perfused hearts, 30-min global ischemia followed by reperfusion resulted in a significant increase in norepinephrine (NE) overflow immediately upon reperfusion and significant decline in contractile force (...

0957-4174/$ see front matter 2012 Elsevier Ltd. A doi:10.1016/j.eswa.2012.02.063 ⇑ Corresponding author. E-mail address: [email protected] (S.-H. Li In order to determine how data mining techniques (DMT) and their applications have developed, during the past decade, this paper reviews data mining techniques and their applications and development, through a survey of literature and the cla...

0957-4174/$ see front matter 2012 Elsevier Ltd. A doi:10.1016/j.eswa.2012.02.063 ⇑ Corresponding author. E-mail address: [email protected] (S.-H. Li In order to determine how data mining techniques (DMT) and their applications have developed, during the past decade, this paper reviews data mining techniques and their applications and development, through a survey of literature and the cla...

The presence of the potent hallucinogenic psychoactive chemical N,N-dimethyltryptamine (DMT) in the human body has puzzled scientists for decades. Endogenous DMT was investigated in the 1960s and 1970s and it was proposed that DMT was involved in psychosis and schizophrenia. This hypothesis developed from comparisons of the blood and urine of schizophrenic and control subjects. However, much of...

WINTER, J. C., R. A. FILIPINK, D. TIMINERI, S. E. HELSLEY AND R. A. RABIN. The paradox of 5-methoxyN,N -dimethyltryptamine: An indoleamine hallucinogen that induces stimulus control via 5-HT 1 A receptors . PHARMACOL BIOCHEM BEHAV 65 (1) 75–82, 2000.—Stimulus control was established in rats trained to discriminate either 5-methoxyN,N -dimethyltryptamine (3 mg/kg) or ( 2 )-2,5-dimethoxy-4-methyl...

This paper describes discrete multi-tone (DMT) line coding, which has become the standard asymmetric digital subscriber line (ADSL) modulation technique as selected by the American National Standards Institute (ANSI) T1E1 committee. Presented here is an overview of DMT ADSL including quadrature amplitude modulation (QAM) encoding, rate-adaptation, bitswapping as well as some of the overall adva...