نتایج جستجو برای: dlbcl lymphoma

تعداد نتایج: 102737  

Journal: :Blood 2005
Silvia Bea Andreas Zettl George Wright Itziar Salaverria Philipp Jehn Victor Moreno Christof Burek German Ott Xavier Puig Liming Yang Armando Lopez-Guillermo Wing C Chan Timothy C Greiner Dennis D Weisenburger James O Armitage Randy D Gascoyne Joseph M Connors Thomas M Grogan Rita Braziel Richard I Fisher Erlend B Smeland Stein Kvaloy Harald Holte Jan Delabie Richard Simon John Powell Wyndham H Wilson Elaine S Jaffe Emili Montserrat Hans-Konrad Muller-Hermelink Louis M Staudt Elias Campo Andreas Rosenwald

Gene-expression profiling has identified 3 major subgroups of diffuse large B-cell lymphoma (DLBCL): germinal center B-cell-like (GCB), activated B-cell-like (ABC), and primary mediastinal DLBCL (PMBCL). Using comparative genomic hybridization (CGH), we investigated the genetic alterations of 224 cases of untreated DLBCL (87 GCB-DLBCL, 77 ABC-DLBCL, 19 PMBCL, and 41 unclassified DLBCL) previous...

2014
Ai Sato Naoya Nakamura Minoru Kojima Ken Ohmachi Joaquim Carreras Yara Yukie Kikuti Hiroki Numata Daisuke Ohgiya Kei Tazume Jun Amaki Makiko Moriuchi Mitsuki Miyamoto Yasuyuki Aoyama Hidetsugu Kawai Akifumi Ichiki Ryujiro Hara Hiroshi Kawada Yoshiaki Ogawa Kiyoshi Ando

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant lymphoma. The incidence of Epstein-Barr virus (EBV)-positive DLBCL in Asian and Latin American countries ranges from 8 to 10%. The prognosis of patients with EBV-positive DLBCL is controversial. To compare the clinical outcome of EBV-positive and EBV-negative patients with DLBCL in the rituximab era, we analyzed 239 p...

2015
Young Jun Chai Jun Hyun Hong Do Hoon Koo Hyeong Won Yu Joon-Hyop Lee Hyungju Kwon Su-jin Kim June Young Choi Kyu Eun Lee

PURPOSE Primary thyroid lymphoma (PTL) is a rare disease and it has been investigated in a limited number of studies. The present multicenter study evaluated the clinical features and treatment outcomes of PTL. METHODS The medical records of patients diagnosed with PTL between 2000 and 2013 in three centers were retrospectively reviewed. RESULTS The study included 11 men and 27 women with a...

2016
Taishi Takahara Keitaro Matsuo Masao Seto Shigeo Nakamura Shinobu Tsuzuki

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant lymphoma; it derives from germinal center B cells. Although DLBCL harbors many genetic alterations, synergistic roles between such alterations in the development of lymphoma are largely undefined. We previously established a mouse model of lymphoma by transplanting gene-transduced germinal center B cells into mice. He...

Journal: :International journal of oncology 2010
Rachel E Culpin Stephen J Proctor Brian Angus Stephen Crosier John J Anderson Tryfonia Mainou-Fowler

The microRNAs are endogenous, non-coding RNAs that play key roles in a range of pathophysiological processes by up- or down-regulating gene expression. Recent studies have shown that some microRNAs have oncogenic or tumour suppressor activity. Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma with a heterogeneous biology, which has impeded the clinical assessment of ...

2015
Lina Quan Xue Chen Aichun Liu Yan Zhang Xiuchen Guo Shujie Yan Yue Liu Luwen Zhang

Epstein-Barr virus-positive diffuse large B-cell lymphoma (EBV+DLBCL) is an aggressive malignancy that is largely resistant to current therapeutic regimens, and is an attractive target for immune-based therapies. Anti-programmed death-1 (PD-1) antibodies showed encouraging anti-tumor effects in both preclinical models and advanced solid and hematological malignancies, but its efficacy against E...

2014
Carla Casulo W. Richard Burack Jonathan W. Friedberg

Histologic transformation (HT) refers to a biologic event leading to the development of a high-grade, aggressive non-Hodgkin lymphoma in patientswith anunderlying follicular lymphoma (FL). Transformation to diffuse large B-cell lymphoma (DLBCL) or Burkitt lymphoma is also known to take place in other subtypes of indolent lymphoma such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small...

Journal: :journal of medical microbiology and infectious diseases 0
noushin lotfi mashhad, iran maryam rastin mashhad, iran parisa shoaei isfahan,iran bahram memar mashhad, iran nafiseh sadat tabasi mashhad, iran zohreh mahmoudi mashhad, iran

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

Journal: :Blood 2001
R M Braziel D A Arber M L Slovak M L Gulley C Spier C Kjeldsberg J Unger T P Miller R Tubbs C Leith R I Fisher T M Grogan

The Revised European-American Lymphoma classification gives Burkitt-like lymphoma (BLL) provisional status, leaving unresolved the differential diagnosis with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). This study compared the biologic features of adult BLL and DLBCL. The phenotypic distinction between BLL and DLBCL was determined by immunohistochemical staining of frozen t...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2015
M Testoni E Zucca K H Young F Bertoni

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults, accounting for 35%-40% of all cases. The combination of the anti-CD20 monoclonal antibody rituximab with anthracycline-based combination chemotherapy (R-CHOP, rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) lead to complete remission in most and can cure more than half of patients with DLBCL. ...

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