Alcohols, trimethylsilyl ethers and thiols were efficiently converted to their corresponding carbonyl and disulfides compounds using o-xylylenebis (triphenylphosphonium) dibromochromate (XTPPDBC). This reagent can selectively oxidize thiols to disulfides in the presence of alcohols and trimethylsilyl ethers in acetonitrile at room temperature.

Controlled degradability in response to the local environment is one of the most effective strategies to achieve spatiotemporal release of genes from a polymeric carrier. Exploiting the differences in reduction potential between the extracellular and intracellular environment, disulfides are frequently incorporated into the backbone of polymeric drug delivery agents to ensure efficient intracel...

The copper-catalyzed cyanation of disulfides by azobisisobutyronitrile (AIBN) was developed, leading to thiocyanates in moderate to good yields. This procedure tolerates a series of functional groups, such as chloro, nitro, methyl and methoxycarbonyl in the phenyl ring of disulfides. Notably, it enables the use of two ArS units in (ArS)2. CuI was found to be essential for the in situ formation ...

H [PV Mo O ] catalyzed oxidation of thiols to related disulfides under microwave irradiation(MW). 5 2 10 40 Hydrogen Peroxide as an oxidizing reagent under mild conditions carried out this reaction. This system provides an efficient convenient and practical method for the syntheses of symmetrical disulfides. In this work, the comparisons among the Keggin and Dawson type polyoxometalates are add...

the difficult to handle and store zinc borohydride, zn(bh4)2, is stabilized by supporting it on polyvinylpyridine. this new mild, efficient, selective, and regenerable polymer supported borohydride reducing agent reduces a variety organic compounds such as, aldehydes, a-b-unsaturated carbonyl compounds, acid chlorides, epoxides, disulfides, as well as reductive acetylation of carbonyl compounds...

We have synthesized a new reagent-N,N'-dimethyl-N,.,V.bis(mercaptoacetyl)hydrazine(DMH)-for the reduction of disulfide bonds in proieins. DMH reduce.s disulfide bonds ? times faster than does dithiothreitol (DTT) in water at pH ?. DMH reduces mixed disulfides of cvsteine proteases (papain and ficin) especially rapdily i30 ti-.r faster than DTT). DMH (eo = -0.300 V) reduces noncl'clic disulfides...

Numerous lines of mouse lymphoid tumors (13 of 22 tested) showed, with increased sensitivity, a property of normal mouse splenic lymphocytes, the potential for growth promotion in vitro by specific thiols added to standard culture media. For lymphoma L1210 (V), structure activity relationships were examined; 9 of 30 thiols promoted growth; the most active was alpha-thioglycerol, effective at 0....

The observation of peaks corresponding to both disulfide-bonded and reduced peptides in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra of disulfides could suggest that the samples are either mixtures prior to analysis or that the measurement process has converted single compounds into mixtures. This is an important distinction when characterizing potentially...