A 29-year-old male presented to the Royal Alexandra Hospital ED on the evening of St. Patrick’s day in 2001. His presenting complaint was general malaise, and he was well known to the department for a variety of previous mixed ingestions and minor injuries. His history was significant for alcohol abuse, with the last ethanol ingestion approximately 18 hours earlier. He was a disheveled man who ...

Dishevelleds are modular proteins that lie at the crossroads of divergent Wnt signaling pathways. The DIX domain of dishevelleds modulates a beta-catenin destruction complex, and thereby mediates cell fate decisions through differential activation of Tcf transcription factors. The DEP domain of dishevelleds mediates planar polarity of cells within a sheet through regulation of actin modulators....

seed protein quality is an important topic in the production of soybean. the quality of soybean proteins is limited by anti-nutrient proteins and low levels of essential sulfur amino acids. in this study, protein content and solubility of six cultivars were evaluated and seed storage proteins were analyzed using sds-page and scanning densitometry. the results showed that seed storage protein ba...

Background: In the absence of Wnt stimulation, the transcriptional cofactor b-catenin is destabilized via phosphorylation by protein kinase GSK3b in complex with Axin family members. In the ‘‘canonical’’ Wnt signaling pathway, Disheveled (Dvl) is required to functionally inhibit the activity of the GSK3b/Axin complex and thereby stabilize b-catenin. Yet, the mechanisms that underlie Wnt regulat...

The precise number and pattern of axonal connections generated during brain development regulates animal behavior. Therefore, understanding how developmental signals interact to regulate axonal extension and retraction to achieve precise neuronal connectivity is a fundamental goal of neurobiology. We investigated this question in the developing adult brain of Drosophila and find that it is regu...

Convergent extension (CE) movement of cells is one of the fundamental processes that control the organized morphogenesis of tissues and organs. The molecular events connecting the noncanonical Wnt pathway and CE movement, however, are not well understood. We show that subcellular localization of Daam1, an essential component of noncanonical Wnt signaling, changes dynamically during notochord fo...