The severity of liver disease is assessed by scoring systems, which include the conventional coagulation test prothrombin time-the international normalized ratio (PT-INR). However, PT-INR is not predictive of bleeding in liver disease and thromboelastometry (ROTEM) has been suggested to give a better overview of the coagulation system in these patients. It has now been suggested that coagulatio...

In the practice of medicine, multiple scores and prognostic systems have been developed to quantify disease severity, assess prognosis, and guide therapeutic interventions. The Glasgow Coma Scale, the Model for End Stage Liver Disease (MELD), and the American Society of Anesthesiologists Physical Status Classification are but a few examples. Heterogeneity in the practice of intensive care medic...

BACKGROUND The aim of this study was to describe the spectrum of disease in children with acute pancreatitis and assess predictors of severity. METHODS Children (≤ 18 years) admitted to a single institution with acute pancreatitis from 2000 to 2009 were included. The accuracy of the Ranson, modified Glasgow, and pediatric acute pancreatitis severity (PAPS) scoring systems for predicting major...

OBJECTIVE To analyze the effectiveness of the Marshall scoring system to evaluate the severity of acute pancreatitis (AP). METHODS We performed a prospective, observational study in 39 patients with AP evaluated by the Marshall scoring system and the Ranson criteria (admission and 48 hours). We assessed the progression of the disease for seven days and compared the data of the two criteria. ...

A simple clinical neurological test was developed to evaluate response to gene therapy in a preclinical canine model of X-linked myotubular myopathy (XLMTM). This devastating congenital myopathy is caused by mutation in the myotubularin (MTM1) gene. Clinical signs include muscle weakness, early respiratory failure, and ventilator dependence. A spontaneously occurring canine model has a similar ...

Background: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are 2 inflammatory indicators that increase in many pathologic and physiologic conditions. Pemphigus vulgaris (PV) is an autoimmune skin disease in which autoantibodies against desmogleins cause acantholysis. In this study we have measured ESR and CRP levels in patients with PV to evaluate the relationship between an ...