INTRODUCTION AND OBJECTIVES New oral anticoagulants require dosing adjustment according to renal function. We aimed to determine discordance in hypothetical recommended dosing of these drugs using different estimated glomerular filtration rate equations in patients with atrial fibrillation. METHODS Cross-sectional analysis of 910 patients with atrial fibrillation and an indication for oral an...

BACKGROUND Despite recommendations favouring review of cancer pathology specimens for patients being treated at an institution other than the one that produced the initial pathology report, data regarding discordance rates and their potential clinical impact remain limited, particularly for breast cancer. At the QEII Health Sciences Centre in Halifax, Nova Scotia, it was routine practice to rev...

OBJECTIVE To examine in monochorionic pregnancies the possible value of intertwin discordance in nuchal translucency (NT) thickness in the prediction of early fetal death or severe twin-twin transfusion syndrome (TTTS). METHODS In 512 monochorionic twin pregnancies NT was measured at 11 to 13 + 6 weeks' gestation and regression analysis was used to determine the significance of the associatio...

nosis)) AND discordance[Title/Abstract]) AND lymphoma)) OR ((lymphoma[Title]) AND pathology[Title]). The pooled major discordance frequency was calculated using Neyeloff, Fuchs and Moreira’s Excel random effects model (2012). Weighted averages using a random-effects model are reported with 95% confidence intervals with continuity correction. Results: Eight (8) articles evaluating and differenti...

Abstract We show that a combined analysis of cosmic microwave background anisotropy power spectra obtained by the Planck satellite and luminosity distance data simultaneously excludes flat universe cosmological constant at 99% confidence level. These results hold separately when combining with three different sets: two determinations Hubble from Riess et al. Freedman al., Pantheon catalog high-...

A case of monochorionic-monoamniotic (MCMA) twin pregnancy with growth discordance because of difference of cord diameter in forked umbilical cord is reported.MCMA twins were diagnosed at 12 weeks of gestation and twin growth discordance was considered during the follow-up twice-weekly visits to the ultrasound and prenatal care units. The pregnancy was terminated at 34 weeks. Two live female ba...

BACKGROUND Lymphomas are common malignancies that have various subtypes with many overlapping histologic, immunophenotypic and genetic features. Therefore, discordance in classifying lymphoma among pathologists may be encountered. But this issue is not well characterized. We conducted the present study to demonstrate discordances among Thai hematopathologists as well as to highlight common argu...

We describe new methods for characterizing gene tree discordance in phylogenomic data sets, which screen for deviations from neutral expectations, summarize variation in statistical support among gene trees, and allow comparison of the patterns of discordance induced by various analysis choices. Using an exceptionally complete set of genome sequences for the short arm of chromosome 3 in Oryza (...