BACKGROUND Fingolimod (FTY) and dimethyl fumarate (DMF) are multiple sclerosis (MS) oral therapies that became available in 2010 and 2013, respectively. OBJECTIVE The objective of this article is to compare discontinuation rates, efficacy, and adverse events (AEs) of FTY and DMF over two years. METHODS Patients prescribed FTY or DMF at the Rocky Mountain MS Center at University of Colorado ...

INTRODUCTION The Reasons for Antipsychotic Discontinuation Interview (RAD-I) was developed to assess patients' perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct e...

Methods We performed a retrospective medical charts review in all JIA patients who received LFN between Jan 2006 to Mar 2011 from our outpatient Pediatric Rheumatology Clinics. We collected data of: gender, age, type of JIA, date of onset, date of diagnosis, date of first DMARD, uveitis, reason to indiciate LFN, concomitant therapies, reason to discontinuation, joint activity (tender and swolle...

The progestogen-only pill (POP), minipill, is quite an effective second line contraceptive. Despite this, it is used relatively infrequently except during lactation. The main reason for this is that women on POP often have abnormal bleeding patterns, with an increased frequency of bleeding, lengthened cycles, breakthrough bleeding, spotting and prolonged bleeding. These menstrual disturbances a...

INTRODUCTION A prespecified pooled analysis of two placebo-controlled, phase 3 trials evaluated whether the number of prior anticholinergics used or reason for their discontinuation affected the treatment response to onabotulinumtoxinA 100U in overactive bladder (OAB) patients with urinary incontinence (UI). METHODS Patients with symptoms of OAB received intradetrusor injections of onabotulin...

BACKGROUND Haemorrhagic complications, including epistaxis, are the main reason for discontinuation of antiplatelet therapy in patients after stent implantation which increases risk of in-stent thrombosis. AIM To evaluate the incidence of bleeding complications leading to premature discontinuation of antiplatelet therapy in patients after percutaneous coronary intervention (PCI) with stent im...

BACKGROUND Despite the significant benefits of secondary prevention (SP) medication after acute myocardial infarction (MI), evidence suggests that these medications are neither consistently prescribed nor appropriately adhered to by patients. The aim of this study was to investigate the role of general practitioners (GPs) and patients regarding discontinuation of SP medication after MI and reas...

very clear. You say “Moreover, the well-known inverse-J relation between the woman’s age and chance of success was observed. On the contrary, risk of discontinuation globally increased as the woman’s age increased.” It might be clearer to say “The well-known inverse-J relation between the woman’s age and chance of success was observed, as expected. However, the risk of discontinuation globally ...