Cadherins have been thought to facilitate the assembly of connexins (Cxs) into gap junctions (GJs) by enhancing cell-cell contact, however the molecular mechanisms involved in this process have remained unexplored. We examined the assembly of GJs composed of Cx43 in isogenic clones derived from immortalized and nontransformed rat liver epithelial cells that expressed either epithelial cadherin ...

ESCRT-III undergoes dynamic assembly and disassembly to facilitate membrane exvagination processes including multivesicular body (MVB) formation, enveloped virus budding, and membrane abscission during cytokinesis. The AAA-ATPase Vps4 is required for ESCRT-III disassembly, however the coordination of Vps4 ATP hydrolysis with ESCRT-III binding and disassembly is not understood. Vps4 ATP hydrolys...

In this article, a personal computer disassembly cell is presented. With this cell, a certain degree of automatism is afforded for the non-destructive disassembly process and for the recycling of these kinds of mass-produced electronic products. Each component of the product can be separated. The disassembly cell is composed of several sub-systems, each of which is dedicated to the planning and...

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases Silvia A. Purro, Soledad Galli, and Patricia C. Salinas* 1 Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK 2 Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK * Correspondence to: Patricia C. Salinas, E-mail: p.sali...

Disassembly of the apical junctional complex (AJC) together with actin cytoskeleton alterations are among the initial events for the development of epithelial cancer. The cell signaling pathways for these processes have been analyzed separately. However, the existence of a link between these two events has not been defined. In this study, using the extracellular calcium depletion model, we anal...

Ribosome recycling factor (RRF), coded for by the frr locus, is involved in the disassembly of post-termination complexes and recycling of the ribosomes for a fresh round of initiation in bacteria and in eukaryotic organelles. In a cross-species-complementation experiment, it was shown that the Thermus thermophilus RRF protein lacking five amino acids from its C-terminal end (deltaC5TthRRF) but...

Manufacturing industries are beginning to face one of the consequences resulting from the rapid development which has occurred during the last decade. The most evident effect is that landfill capacity is being used up. Therefore, a systematic approach to recycling is both urgent and imperative. It has been also recognized that appropriate disassembly of used products is necessary in order to ma...

Nowadays, global sustainability is the central issue in recycling and, increasingly, in manufacturing. Recycling used products can save energy, natural resources, and landfill space, and can reduce air pollution. It can give used products new lives. The study of disassembly is needed in order to make recycling economical, and disassembly sequence generation (DSG) plays an important role. An app...