BACKGROUND Directly observed therapy (DOT) is a widely recommended and promoted strategy to manage tuberculosis (TB), however, there is still disagreement about the role of DOT in TB control and the impact it has on reducing the acquisition and transmission of drug resistant TB. This study compares the portion of drug resistant genotype clusters, representing recent transmission, within and bet...

BACKGROUND Identifying new approaches to tuberculosis treatment that are effective and put less demand to meagre health resources is important. One such approach is community based direct observed treatment (DOT). The purpose of the study was to determine the cost and cost effectiveness of health facility and community based directly observed treatment of tuberculosis in an urban setting in Tan...

This study aims to assess the effectiveness of Video Directly Observed Therapy (VDOT) compared (DOT) in improving medication adherence TB patients. The method used is a systematic review using CINAHL, PubMed, and Scopus databases. results showed that 2 articles discussed routine treatment monitoring for face-to-face DOT at patient's home or agreed with location during weekdays, 8 by meeting hea...

SETTING A government health system in southern Thailand where the directly observed treatment, short-course (DOTS) strategy has been implemented. OBJECTIVE To compare the practice of actual directly observed treatment (DOT) and the observer sustainability for different types of observer. METHODS During 1999-2000, 411 patients with new smear-positive pulmonary tuberculosis were followed up. ...

SETTING The Pathanamthittha District of Kerala State, India, where the directly observed treatment, short-course (DOTS) programme was started in October 1994. OBJECTIVE To determine the frequency with which direct observation actually occurred within a district-level DOTS programme, and the association of treatment observation with treatment outcome under programme conditions. DESIGN This r...

In the era of highly effective anti-retroviral therapy (ART), data show a significant difference in treatment outcomes between injecting drug users (IDUs) and non-IDUs. Factors that may contribute to suboptimal treatment outcomes in IDUs include delayed access to ART, competing comorbid diseases, psychosocial barriers and poor long-term adherence to ART. This review describes and compares sever...