An adsorption study of dipeptides onto different Zr-based metal–organic frameworks (Zr-MOF) unravelled key parameters affecting peptide-MOF interactions in aqueous conditions, and provides unique molecular insights for future designs.

Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of ...

A 30 cm segment of the duodenum, jejunum, or ileum of normal human volunteers was perfused, on separate occasions, with test solutions containing either glycylglycine, free glycine, glycylleucine, or equimolar amounts of free glycine and free leucine. Luminal fluid contained no hydrolytic activity against glycylglycine and minimal activity against glycylleucine. In each intestinal segment, amin...

Neurofilament-L (NF-L) is a major element of the neuronal cytoskeleton and is essential for neuronal survival. Moreover, abnormalities in NF-L result in neurodegenerative disorders. Carnosine and the related endogeneous histidine dipeptides prevent protein modifications such as oxidation and glycation. In the present study, we investigated whether histidine dipeptides, carnosine, homocarnosine,...

This study was performed to examine the effect of dietary level of vitamin B6 on the concentrations of carnosine and anserine, antioxidants, in the heart of rats. Analysis using UPLC-MS/MS showed that the concentrations of these dipeptides in the 7 and 35 mg pyridoxine HCl/kg groups were significantly higher than those in the 1 mg pyridoxine HCl/kg group, implying the novel role of dietary vita...

The application of six novel α,β-dipeptides as chiral organocatalysts in the asymmetric Michael addition reaction between enolizable aldehydes and N-arylmaleimides or nitroolefins is described. With N-arylmaleimides as substrates, the best results were achieved with dipeptide 2 as a catalyst in the presence of aq. NaOH. Whereas dipeptides 4 and 6 in conjunction with 4-dimethylaminopyridine (DMA...

Equilibrium constants have been measured potentiometrically for the mixed-ligand complexes, copper (U)-amines (A)-dipeptides (L). The aromatic amines (A) used are 5-nitro-l,lO-phenanthroline (Nphen), 2,2'-pyridyl benzimidazoline (pybz), 1,lO-phenanthroline (phen) and 2,2'-pyridyl imidazoline (pyz). The dipeptides used are glycylglycine (gg), glycyl-l-alanine (ga) and glyeyl-l-Ieucine (gl), The ...

1 . The intestinal absorption of carnosine, glycylglycine, glycyl-D-phenylalanine, glycyl-L-phenylalanine, glycyl-L-proline and L-prolylglycine were investigated after intraluminal injection of dipeptide into anaesthetized rats. 2. With all six dipeptides, the intact substance was detected by ion-exchange chromatography in blood samples taken from the superior mesenteric vein. 3. The rate of hy...

We studied diastereoisomeric dipeptides, containing two chiral centers, by comparing ab initio calculations with laser desorption jet-cooling experiments. We studied the hetero-dipeptides LL–VF (L-Val-L-Phe) and DL–VF and the homo-dipeptides LL–FF (L-Phe-L-Phe) and LD–FF. Changing one of the chiral centers in each molecule leads to changes in the spectra that can be used to distinguish between ...

Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolite...