STUDY QUESTION Does an association exist between high normal numbers of CGG trinucleotide repeats on the fragile X mental retardation 1 (FMR1) gene and diminished ovarian reserve (DOR)? SUMMARY ANSWER This large data set demonstrated that a high normal number of CGG repeats (35-54 repeats) on the FMR1 gene was not significantly correlated with DOR. WHAT IS KNOWN ALREADY The FMR1 premutation...

OBJECTIVES The diminished ovarian reserve (DOR) is a condition characterized by a reduction in the number and/or quality of oocytes. This primary infertility disorder is usually accompanied with an increase in the follicle-stimulating hormone (FSH) levels and regular menses. Although there are many factors contributing to the DOR situation, it is likely that many of idiopathic cases have geneti...

Background: Diminished ovarian reserve (DOR) predicts decreased response to stimulation. Low serum anti-Mullerian hormone (AMH) is associated with DOR. AMH a marker of and acts as predictor stimulation protocol. The up regulated by vitamin D via elements that bind the receptor. Vitamin supplementation has role in increasing AMH. objective was compare combined effect DHEA vs alone on Methods: Th...

Though a widely utilized term and clinical concept, ovarian reserve (OR) has been only inadequately defined. Based on Medline and PubMed searches we here define OR in its various components, review genetic control of OR, with special emphasis on the FMR1 gene, and discuss whether diminished OR (DOR) is treatable. What is generally referred to as OR reflects only a small portion of total OR (TOR...

BACKGROUND Diminished ovarian reserve (DOR) is a heterogeneous disorder causing infertility, characterized by a decreased number of oocytes, the genetic cause of which is still unknown. METHODS AND RESULTS We describe a family with a new unbalanced X;18 translocation der(X) associated with either fully attenuated or DOR phenotype in the same family. Cytogenetics and array comparative genomic ...

STUDY QUESTION Is diminished functional ovarian reserve (DFOR) associated with low androgen levels? SUMMARY ANSWER Low androgen levels are associated with DFOR at all ages. WHAT IS KNOWN ALREADY Androgen supplementation via dehydroepiandrosterone (DHEA) has been reported to improve functional ovarian reserve (FOR); pregnancy rates in IVF cycles are associated with how well DHEA converts to ...

Abstract Anti-Mullerian hormone (AMH) and testosterone (T) both play distinct roles in the early stages of folliculogenesis. However, relationship between serum T AMH levels is poorly understood. This study aimed to investigate association infertile women. A total 1935 women aged 20–46 years were included cross-sectional divided into four quartile groups (Q1 Q4) based on levels. Compared subjec...

Background: Infertility remains a significant issue in the world of health. Now Assisted Reproductive Technology (ART) is widely used to help couples with infertility. In ART diminish ovarian reserve patients have very low success rate pregnancy. To Diminished Ovarian Reserve (DOR), research conducted using an animal model. vinylcychlohexene diepoxide (VCD) has ovoto...

Variability in the subfertile patient population excludes the possibility of a single approach to controlled ovarian stimulation (COS) covering all the requirements of a patient. Modern medical science has made great advances in the understanding and the development of new drugs, treatment options and quantitative methods that can identify single patient characteristics. Factors that reduce fol...