The title compound, C(30)H(32)FNO(2), was synthesized by the reaction of dimedone with 4-fluoro-benzaldehyde and p-toluidine in water. The dihydro-pyridine and both of the cyclo-hexenone rings are not planar and have flattened boat conformations. The dihedral angle between the planar aromatic rings is 15.33 (3)°. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link the mol-ecules...

The derivatives of fused pyrimidines are valued not only for their rich and varied chemistry, but also for many important biological properties [1 – 3]. Among them, the pyridodipyrimidines (PDP) have been shown to exhibit antibacterial and antiviral properties [4, 5] as well as NAD-type redox catalytic activity [6 – 10]. A few methods are reported in the literature for the preparation of pyrido...

SmCl3 (20 mol%) has been used as an efficient catalyst for reaction between aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione at 120°C to give 1,8-dioxo-octahydroxanthene derivatives in high yield. The same reaction in water, at room temperature gave only the open chain analogue of 1,8-dioxo-octahydroxanthene. Use of eco-friendly green Lewis acid, readily available catalyst and easy isol...

Technical iodine was found to catalyze the condensation between 2-aminobenzohydrazide (1) and some aldehydes and ketones in absolute ethanol under mild conditions to afford hydrazone and quinazoline derivatives, respectively. Condensation of 1 with terephthalaldehyde (2) in 1 : 1 molar ratios afforded the hydrazone 3, while hydrazone 4 was formed on using a double molar ratio of 1. On the other...

efficient and one-pot synthesis of 1,8-dioxo-octahydroxanthenes was described by knoevenagel condensation, michael addition and cyclodehydration of dimedone. this reaction was carried out through condensation of dimedone and various aromatic aldehydes in the presence of task-specific brønsted acidic ionic liquid under solvent free conditions. the catalyst could be recycled five times without si...

In this work, Fe3O4@nano-walnut shell/BIII (FNWSB), as a reusable and new catalyst was prepared then characterized by FT-IR, XRD, FESEM, EDS-MAP, TGA. This used for synthesis of tetrahydrobenzo[a]xanthen-11-ones via three-component, one-pot condensation reaction dimedone, β-naphthol, aromatic aldehydes. An uncomplicated work-up, high yields product, short times, use low-cost are considerable ad...

silica-bonded n-propyltriethylene-tetramine (sbnptt) was found as an efficient solid base for the synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4h-chromenes. chromene derivatives were obtained via the three-component condensation reaction of aromatic aldehydes, malononitrile, and dimedone at 80 oc under solvent-free conditions. the heterogeneous solid base showed much the same efficiency when u...

A simple and highly efficient protocol for the synthesis of derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 8-hexahydro-1H-quinazoline-5-one from 5, 5-dimethyl cyclohexane-1, 3-dione (4a–4h) (dimedone) has been described. The aryl aldehydes were substituted with thiourea in presence synthesized zinc ferrite nanocatalyst, which increased yield under reflux through condensation, followed ...