Background: The gene expression profile of a tissue averages the expression profiles of all cells in this tissue. Digital tissue deconvolution (DTD) addresses the following inverse problem: Given the expression profile y of a tissue, what is the cellular composition c of that tissue? If X is a matrix whose columns are reference profiles of individual cell types, the composition c can be compute...

Background & Aims: Endurance training has an important role in the prevention and adjuvant therapy of breast cancer. The aim of the present study was to investigate the role of endurance training on miR- 155 expression, signal transducer and activator of transcription-3 (STAT3) gene expression, and interleukin 6 (IL-6) protein in breast cancer tumor in mice. Methods: In this study, 16 female Ba...

Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.  Methods: In this study, a gene expression profile from a microarray study was selected for more investigation. Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties....

Background: Vitrification of oocytes is a fast-freezing technique, which may affect the quality of the human oocyte, and consequently affects the embryo development, pregnancy and birth. The aim of the current study was to investigate the consequence of in-vitro vitrification on maturation status of immature human oocytes, additionally, expression levels of stress, and apoptosis related genes. ...

introduction: oxygen tension is one of the most important stimuli in stem cell biology. in this study, we investigate the considerable influence of hypoxia on cx43 gene expression as one of the most important gap junction on the surface of mesenchymal stem cells. methods: mesenchymal stem cells were isolated from c57bl/6 mouse bone marrow and cultured in dmem medium under low oxygen tension (1%...

Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...

eight samples of flowering tops from six species of the genus crataegus l., commonly called hawthorn, from different geographic locations of iran were standardized according to german pharmacopoeia monograph on crataegi folium cum flore (hawthorn leaf with flower) by high-performance thin-layer chromatograph-ic (hptlc) fingerprinting combining with digital scanning profiling of their major poly...

BACKGROUND Botrytis cinerea, a haploid Euascomycete fungus that infects numerous crops, has been used as a model system for studying molecular phytopathology. Botrytis cinerea adopts various modes of infection, which are mediated by a number of pathogenicity and virulence-related genes. Many of these genes have not been reported previously. OBJECTIVES This study aimed to investigate developme...

suicide is a major public health concern, with approximately one million people committing suicide world-wide each year .risk factors for suicidal behavior include, psychiatric and medical illness, impulsivity, aggression, alcohol and drug abuse specially stimulants, and  stress. neurobiological, brain mappings and biochemical studies have revealed that suicide victims experiencing a large numb...