The dose-response characteristics of dieldrin-mediated enhancement of liver tumour formation in CF-1 mice were analysed, using existing tumour data from chronic feeding studies at six levels of continuous exposure, involving a total of greater than 1500 animals. The dose-response relationship can be expressed as: Dx X Tx = D0 X T0 = constant, where T0 = the median liver tumour induction period ...

A study was completed to investigate temporal trends of organochlorine pesticides (OCPs; aldrin, chlordane, dieldrin, heptachlor, hexachlorbenzene, and DDT) and polychlorinated biphenyls (PCBs) in sewage sludge. Between 2004 and 2006 the concentration of OCPs and PCBs in Australian sewage sludge (n=829) was consistently <1000mugkg(-1) dry solids DS. Dieldrin, chlordane and DDE were detected in ...

Stringent conditions with regard to cleanliness are laid down for the attention of public authorities concerned with the spraying of dieldrin formulations. Protective clothing must be worn and this must be changed frequently. Personal cleanliness is imperative. Since sprayers are often operating in rugged country for days at a time it is not easy for these conditions to be followed and it has b...

Carbaryl was well absorbed from the small intestine of rats. In the cytosol fraction of intestinal mucosa, it was bound to a smallmolecular component (M. W. 2,200 daltons). In serum, carbaryl was bound mainly to albumin and partly to globulins. Dieldrin was slowly absorbed from small intestine. The peak of dieldrin concentration in blood was observed 2.5 hr after the administration. Binding of ...

Immunomodulation by environmental chemical contaminants and the role immune parameters play in toxicity and risk assessment studies is of increasing concern. Although considerable evidence has indicated that various xenobiotics may be immunosuppressive, little attention has been directed toward ascertaining a specific cellular locus which could be responsible for the impaired immune responsiven...

Dieldrin and DDE are environmental metabolites of the organochlorine pesticides aldrin DDT, respectively. During pregnancy, these chemicals can quickly infiltrate through placental barrier, accumulate in amniotic fluid fetus, act as endocrine disruptors (EDs). The aim this study was to investigate effect dieldrin their parental substances at concentrations 1 10 ng/ml on secretion PGE2 PGF2α fro...

In this study we examined the mechanism of action of Dieldrin on the reproductive function in adult male rats. Experimental data suggest that exposure to pesticide at 3 and 6mg/kg/day for 10 consecutive days, induced a dose-dependant decrease of the number and the mobility of epididymal spermatozoa. Testicle histological analysis shows alteration of spermatogenesis with marked reduce of gametes...

Dieldrin is an organochlorine insecticide highly toxic for human beings. Although its exact mechanism of action is not well known, there is evidence that it acts at the cell membrane level. In fact, the lipophilicity of the pesticide as well as that of the phospholipid bilayer present in biological membranes makes the latter a most likely target for the interaction of dieldrin with living organ...