نتایج جستجو برای: dicer1 protein

تعداد نتایج: 1235057  

2015
Mark Brenneman Amanda Field Jiandong Yang Gretchen Williams Leslie Doros Christopher Rossi Kris Ann Schultz Avi Rosenberg Jennifer Ivanovich Joyce Turner Heather Gordish-Dressman Douglas Stewart Weiying Yu Anne Harris Peter Schoettler Paul Goodfellow Louis Dehner Yoav Messinger D. Ashley Hill James F. Amatruda Kenneth S. Chen Julian A. Martinez-Agosto Steven Klein

Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition,  DICER1 syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of  DICER1-associated tumorigenesis are unusual in that tumors typically bear neomorphic missense mutations at on...

2012
Katherine B. Chiappinelli Brian C. Haynes Michael R. Brent Paul J. Goodfellow

DICER1 is essential for the generation of mature miRNAs and other short noncoding RNAs. Several lines of investigation implicate DICER1 as a tumor suppressor. Reduced DICER1 levels and changes in miRNA abundance have been associated with aggressive tumor phenotypes. The global effects of reduced DICER1 on mRNA transcript abundance in tumor cells remain largely unknown. We used short hairpin RNA...

Journal: :The New England journal of medicine 2012
Alireza Heravi-Moussavi Michael S Anglesio S-W Grace Cheng Janine Senz Winnie Yang Leah Prentice Anthony P Fejes Christine Chow Alicia Tone Steve E Kalloger Nancy Hamel Andrew Roth Gavin Ha Adrian N C Wan Sarah Maines-Bandiera Clara Salamanca Barbara Pasini Blaise A Clarke Anna F Lee Cheng-Han Lee Chengquan Zhao Robert H Young Samuel A Aparicio Poul H B Sorensen Michelle M M Woo Niki Boyd Steven J M Jones Martin Hirst Marco A Marra Blake Gilks Sohrab P Shah William D Foulkes Gregg B Morin David G Huntsman

BACKGROUND Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essential for processing microRNAs, have been observed in families with the pleuropulmonary blastoma-family tumor and dysplasia syndrome. Mutation carriers are at risk for nonepithelial ovarian tumors, notably sex cord-stromal tumors. METHODS We sequenced the whole transcriptomes or exomes ...

Journal: :Nature communications 2015
Aliza P Wingo Lynn M Almli Jennifer S Stevens Torsten Klengel Monica Uddin Yujing Li Angela C Bustamante Adriana Lori Nastassja Koen Dan J Stein Alicia K Smith Allison E Aiello Karestan C Koenen Derek E Wildman Sandro Galea Bekh Bradley Elisabeth B Binder Peng Jin Greg Gibson Kerry J Ressler

DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduc...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2013
Zoltan Ungvari Zsuzsanna Tucsek Danuta Sosnowska Peter Toth Tripti Gautam Andrej Podlutsky Agnes Csiszar Gyorgy Losonczy M Noa Valcarcel-Ares William E Sonntag Anna Csiszar

Age-related impairment of angiogenesis is likely to play a central role in cerebromicrovascular rarefaction and development of vascular cognitive impairment, but the underlying mechanisms remain elusive. To test the hypothesis that dysregulation of Dicer1 (ribonuclease III, a key enzyme of the microRNA [miRNA] machinery) impairs endothelial angiogenic capacity in aging, primary cerebromicrovasc...

2016
Mark Brenneman Jiandong Yang Gretchen Williams Leslie Doros Kris Ann Schultz Jennifer Ivanovich Heather Gordish-Dressman Douglas Stewart Weiying Yu Louis Dehner Ashley Hill Lauren V. Ackerman

Pleuropulmonary blastoma (PPB) is the most frequent pediatric lung tumor and often the first indication of a pleiotropic cancer predisposition, DICER1 syndrome, comprising a range of other individually rare, benign and malignant tumors of childhood and early adulthood. The genetics of -associated DICER1 tumorigenesis are unusual in that tumors typically bear neomorphic missense mutations at one...

2018
Xia Wu Yingzhuo Yang Yike Huang Yang Chen Tianying Wang Shuo Wu Lei Tong Yan Wang Lexun Lin Meili Hao Zhao-Hua Zhong Fengmin Zhang Wenran Zhao

Hepatocellular carcinoma (HCC) is one of the common cancers worldwide, especially in developing countries. Although the chronic infections of hepatitis B and C viruses have been established as the etiological factors of HCC, the mechanism for the tumorigenesis and development of HCC is still unclear. The liver-specific microRNA-122 (miR-122), an established tumor-suppressor miRNA, is often down...

2011
Hanna M. Korhonen Oliver Meikar Ram Prakash Yadav Marilena D. Papaioannou Yannick Romero Matteo Da Ros Pedro L. Herrera Jorma Toppari Serge Nef Noora Kotaja

BACKGROUND The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The best-characterized function of miRNAs is gene repression at the post-transcriptional level through the pairing with mRNAs of protein-encoding genes. Small RNAs can also act at the transcriptional level by controlling the epigenetic s...

2013
Galina Feinberg-Gorenshtein Avital Guedj Keren Shichrur Marta Jeison Drorit Luria Yona Kodman Shifra Ash Meora Feinmesser Liat Edry Noam Shomron Abraham Weizman Isaac Yaniv Smadar Avigad

Neuroblastoma (NB) arises from the embryonic neural crest and is the most common extracranial solid tumor in children under 5 years of age. Reduced expression of Dicer1 has recently been shown to be in correlation with poor prognosis in NB patients. This study aimed to investigate the mechanisms that could lead to the down-regulation of Dicer1 in neuroblastoma. We used computational prediction ...

Journal: :Mechanisms of Development 2009
Veena Patil Toshie Kai

lyzes the maturation of micro RNAs (miRNA) by endoribonucleolytic cleavage of double stranded RNA precursors. This process is central to the process of RNA interference. Gene trap experiments abolishing the function of Dicer1 and therefore the production of miRNAs result in embryonic lethality [Bernstein, E. etal., 2003. Dicer is essential for mouse development. Nature Genetics 35, 215–217]. Th...

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