نتایج جستجو برای: dicentric y chromosome

تعداد نتایج: 603928  

Journal: :Genetics 1998
K Ahmad K G Golic

We investigated the fate of dicentric chromosomes in the mitotic divisions of Drosophila melanogaster. We constructed chromosomes that were not required for viability and that carried P elements with inverted repeats of the target sites (FRTs) for the FLP site-specific recombinase. FLP-mediated unequal sister-chromatid exchange between inverted FRTs produced dicentric chromosomes at a high rate...

Journal: :Journal of medical genetics 1977
S H Roberts R T Howell K M Laurence M E Heathcote

A dicentric autosome, tdic(8:22)(p23:p13), was found in all metaphase cells examined from the peripheral blood of a mentally retarded girl. It is suggested that the centromere of chromosome 22 was inactive, allowing the dicentric to behave as a monocentric element. The involvement of acrocentric chromosomes in the stable dicentric autosomes of man is discussed.

Journal: :iranian journal of radiation research 0
s.a. haeri department of radiobiology, novin medical radiation institute, tehran, iran h. mozdarani m. foroghizadeh a. mahmoudzadeh

background: lymphocyte-dicentric assay is the most generally accepted method for biological dosimetry of overexposed individuals. in this study, the frequency of unstable chromosome aberration in blood lymphocytes was used to estimate radiation dose received by individuals. evaluation of dose using a calibration curve produced elsewhere may have a significant uncertainty therefore, experiments ...

Journal: :Journal of applied genetics 2005
Ana I Vásquez-Velásquez Lisette Arnaud-López Luis E Figuera Jorge R Padilla-Gutiérrez Fernando Rivas Horacio Rivera

We describe here a 3-month-old male infant with brachy-plagyocephaly, short neck, widely spaced nipples, mild hypertonia, and ambiguous external genitalia but with both testes in the scrotum and no Müllerian derivates. His karyotype was 45,X,der(Y;9)(q12;p24).ish der(Y;9)(DYZ3+,SRY+,9ptel-) de novo. This patient's impaired sex differentiation is consistent with gonadal dysgenesis and compares w...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
G Hadlaczky T Praznovszky I Cserpán J Keresö M Péterfy I Kelemen E Atalay A Szeles J Szelei V Tubak

A 13,863-base-pair (bp) putative centromeric DNA fragment has been isolated from a human genomic library by using a probe obtained from metaphase chromosomes of human colon carcinoma cells. The abundance of this DNA was estimated to be 16-32 copies per genome. Cotransfection of mouse cells with this sequence and a selectable marker gene (aminoglycoside 3'-phosphotransferase type II, APH-II) res...

Journal: :Molecular biology of the cell 2001
D A Thrower K Bloom

We have used mitotic spindle forces to examine the role of Sir2 and Ku in chromatin compaction. Escherichia coli lac operator DNA was placed between two centromeres on a conditional dicentric chromosome in budding yeast cells and made visible by expression of a lac repressor-green fluorescent fusion protein. Centromeres on the same chromatid of a dicentric chromosome attach to opposite poles ap...

Journal: :Genetics 1985
R T Surosky B K Tye

We have integrated a plasmid containing a yeast centromere, CEN5, into the HIS4 region of chromosome III by transformation. Of the three transformant colonies examined, none contained a dicentric chromosome, but all contained a rearranged chromosome III. In one transformant, rearrangement occurred by homologous recombination between two Ty elements; one on the left arm and the other on the righ...

Journal: :Radiation protection dosimetry 2016
L A Beaton-Green T Barr E A Ainsbury R C Wilkins

In 2014, Health Canada was approached by the Canadian Nuclear Safety Commission to conduct biodosimetry for a possible overexposure 4 y prior to assessment. Dose estimates were determined by means of two cytogenetic assays, the dicentric chromosome assay (DCA) and translocations as measured by the fluorescent in situ hybridization (FISH). As dicentrics are considered to be unstable over time, t...

Journal: :Genetics 1984
J E Haber P C Thorburn D Rogers

Meiotic recombination between a circular and a linear chromosome in Saccharomyces cerevisiae has been investigated. The circle was a haploid-viable derivative of chromosome III constructed by joining regions near the two chromosome ends via a recombinant DNA construction: (HMR/MAT-URA3-pBR322-MAT/HML) and was also deleted for MAL2 (which therefore uniquely marks a linear chromosome III). Recomb...

Journal: :The Journal of Cell Biology 2008
Melissa K. Gardner Julian Haase Karthikeyan Mythreye Jeffrey N. Molk MaryBeth Anderson Ajit P. Joglekar Eileen T. O'Toole Mark Winey E.D. Salmon David J. Odde Kerry Bloom

In budding yeast, the mitotic spindle is comprised of 32 kinetochore microtubules (kMTs) and approximately 8 interpolar MTs (ipMTs). Upon anaphase onset, kMTs shorten to the pole, whereas ipMTs increase in length. Overlapping MTs are responsible for the maintenance of spindle integrity during anaphase. To dissect the requirements for anaphase spindle stability, we introduced a conditionally fun...

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