Aim / Objective: The aim of this study was to evaluate the effect maximal exercise on level cardiac remolding and Atrial Natriuretic Peptide (ANP) in elite athletes as compared sedentary healthy subjects correlation ANP with adaptation athlete’s heart remodeling (if any) Place Duration Study: present carried out at Department Physiology, Army Medical College, collaboration Armed Forces Institut...

Studies in man produce conflicting evidence of the role of the Frank-Starling mechanism in increasing cardiac output during exercise, though animal studies indicate that it may help to improve cardiac performance during severe exertion. Twelve healthy volunteers (mean age 35.8 i 2.8 years) performed graded exercise to exhaustion on a bicycle ergometer in the semisupine position for 8.9 i 0.9 mi...

BACKGROUND Reduced left ventricular (LV) ejection fraction increases the risk of ventricular arrhythmias; however, LV ejection fraction has a low sensitivity to predict ventricular arrhythmias. LV dilatation and mass may be useful to further risk-stratify for ventricular arrhythmias. METHODS AND RESULTS Patients from the Genetic Risk of Assessment of Defibrillator Events (GRADE) study (N=930)...

Thirty-eight patients with end stage renal disease who were on haemodialysis and had recurrent congestive cardiac failure were analysed. Echocardiographic findings were evaluated at start of haemodialysis and after 6 dialysis sessions. Seventeen cases (48%) had diastolic dysfunction, 11 (29%) systolic dysfunction 8 (18%) had normal echocardiogram and 2 (5%) had dilated left ventricle with norma...

The aim of this study was to investigate the effect of combined atropine low-dose dobutamine stress test on left ventricular parameters in adult warmblood horses, to establish a potential protocol for pharmacological stress echocardiography. Seven healthy untrained warmblood horses aged 9 to 22 years were used. Heart rate (HR) and left ventricular B- and M-mode dimensions were recorded at basel...

The effects of developing perinephritic hypertension (2-3 weeks) and a more stable period of perinephritic hypertension (approximately 14 weeks) were examined on indexes of left ventricular (LV) diastolic function in conscious, chronically instrumented dogs. The complete period of diastole was studied using indexes of isovolumic relaxation (tau), early filling (LV +dD/dt), and stiffness (myocar...

BACKGROUND To determine how the tissues that surround the heart affect diastolic and systolic function during the perinatal period, we studied the pressure-diameter relation of the left ventricle in partially delivered fetal lambs. METHODS AND RESULTS We anesthetized (1.5-2.0% halothane, balance O2) and ventilated six pregnant ewes (142-144 days of gestation) and then partially delivered each...

The left ventricular response to severe exercise was studied by telemetering direct measurements of left ventricular diameter (D) and pressure (P) and aortic blood flow from healthy dogs running at speeds up to 30 mph in the field. Severe exercise increased cardiac output from 101 to 478 ml/kg per min, heart rate from 95 to 297 beats/min, stroke volume from 31 to 44 ml, left ventricular isoleng...

The cardiac effects of ethanol were studied in six conscious dogs chronically instrumented for measurement of left ventricular pressure, internal transverse diameter, and outflow. Successive intravenous infusions of ethanol produced blood levels of 120 16 (SEM) mg% (infusion #1) and 311 19 mg% (infusion #2). Stroke volume decreased from 20.1 1.6 ml preinfusion to 17.2 1.9 ml after infusion #1 (...