BACKGROUND Elevated plasma concentrations of leptin, a hormone thought to regulate body composition by influencing food intake/metabolic rate, are prevalent in renal failure patients. The mechanism for these increases is not known, but evidence suggests that simple accumulation due to decreased elimination is insufficient explanation. METHODS We studied the incidence of hyperleptinaemia in 28...

BACKGROUND The control of extracellular volume is a key parameter for reducing hypertension and the incidence of cardiovascular mortality in dialysis patients. In recent years bioimpedance measurement (BIA) has been proven as a non-invasive and accurate method for measuring intracellular and extracellular fluid spaces in man. In addition, plasma atrial natriuretic peptide (ANP) and cyclic guano...

BACKGROUND A recent survey puts the global dialysis population at 535100; of those on peritoneal dialysis, 85% are on continuous ambulatory peritoneal dialysis. Current hyperosmolar dialysis fluids are toxic to peritoneal cells and inhibit certain host-defence functions. An alternative preparation, glucose polymer, has recently been developed. METHODS Mesothelial cell viability, interleukin-6...

The Effects of Peritoneal Dialysis Fluid and its Components on the Differentiation of White Blood Cells into Fibrocytes. (May 2012) Hannah Elizabeth Starke Department of Biology Texas A&M University Research Advisor: Dr. Richard Gomer Department of Biology Kidneys filter out toxins which accumulate in the blood. In order to replace the function of the kidneys in patients with kidney damage, flu...

We tested the possibility that the buffering agents in dialysis bath fluid might contribute to increased endogenous oxalate production in dialyzed patients. Using stable isotope dilution mass spectrometry, we obtained oxalate production rates and pool sizes directly for 10 patients in chronic renal failure, 5 of whom were undergoing continuous ambulatory peritoneal dialysis (lactate-buffered fl...

During peritoneal dialysis solutes and water are transported across the peritoneum, a thin “membrane” lining the abdominal and pelvic cavities. Dialysis fluid containing an “osmotic agent”, usually glucose, is infused into the peritoneal space, and solutes and water pass from the blood into the dialysate (and vice versa). The complex physiological mechanisms of fluid and solute transport betwee...

The effect on hormonal status and intermediary metabolism of a single 6 h dialysis cycle at two different concentrations of dialysate glucose was investigated in six patients on continuous ambulatory peritoneal dialysis. The basal blood glucose level was elevated by 0.5 mmol/l, associated with a threefold increase in basal serum insulin compared with seven normal controls. Blood glucose and ser...

background the chemical and physical quality of water used for dialysis fluid is a vital factor in the patients overall care who receive dialysis. therefore, the water used for this purpose must be treated with advanced methods before being used for dialysis. conclusions the evaluation of hemodialysis water quality showed that these hospitals were not significantly polluted and the water qualit...

Dialysis can be used in severe cases, but may not be well tolerated. In such patients, peritoneal drainage could be an alternative option for fluid removal. We report the case of a newborn with a truncus arteriosus who developed postoperatively a complicated clinical course with right ventricular dysfunction, prerenal condition as well as fluid overload despite diuretic therapy. Dialysis was in...

We in Vicenza began studies on buffers in peritoneal dialysis (PD), leading the pathway toward the use of bicarbonate in fluids (1–3). We analyzed the pathophysiologic pathways of neurotransmission, measuring several substances in the cerebrospinal fluid before and after dialysis (4, 5). In those days, the pressure to shorten hemodialysis treatments provided the impetus for studies on dialysis ...