The KT1000 and KT2000 knee joint arthrometers (MEDmetric Corp, San Diego, California) have been shown to overestimate the measurement of knee joint sagittal laxity. The purpose of this study was to investigate the accuracy of the KT arthrometers as measures of anterior and posterior linear displacement. The anterior and posterior linear displacements of 3 KT arthrometers (2 KT1000 arthrometers ...

Furan is a liver carcinogen and toxicant. Furan is oxidized to the reactive dialdehyde, cis-2-butene-1,4-dial, by microsomal enzymes. This reactive metabolite readily reacts with glutathione nonenzymatically to form conjugates. A high-performance liquid chromatography-electrochemical method for the detection of cis-2-butene-1,4-dial-glutathione (GSH) conjugates in microsomal preparations was de...

Furan is a toxic and carcinogenic compound used in industry and commonly found in the environment. The mechanism of furan's carcinogenesis is not well-understood and may involve both genotoxic and nongenotoxic pathways. Furan undergoes oxidation by cytochrome P450 to cis-2-butene-1,4-dial, which is thought to mediate furan's toxic effects. Consistently, cis-2-butene-1,4-dial readily reacts with...

Object-directed grasping movements are adapted to intended interactions with an object. We address whether adjusting the grasp for object manipulation is controlled habitually, based on past experiences, or by goal-directed planning, based on an evaluation of the expected action outcomes. Therefore, we asked participants to grasp and rotate a dial. In such tasks, participants typically grasp th...

DIAL (dihedral alignment) is a web server that provides public access to a new dynamic programming algorithm for pairwise 3D structural alignment of RNA. DIAL achieves quadratic time by performing an alignment that accounts for (i) pseudo-dihedral and/or dihedral angle similarity, (ii) nucleotide sequence similarity and (iii) nucleotide base-pairing similarity. DIAL provides access to three ali...

When humans grasp objects, the grasps foreshadow the intended object manipulation. It has been suggested that grasps are selected that lead to medial arm postures, which facilitate movement speed and precision, during critical phases of the object manipulation. In Experiment 1, it has been tested whether grasp selections lead to medial postures during rotations of a dial. Participants twisted t...

dialysis: a meta-analysis of randomized controlled trials. Perit Dial Int 2011; 31:179–88. 2. Paniagua R, Ventura MD, Avila–Díaz M, Cisneros A, Vicenté–Martínez M, Furlong MD, et al. Icodextrin improves metabolic and fluid management in high and high-average transport diabetic patients. Perit Dial Int 2009; 29:422–32. 3. Han SH, Ahn SV, Yun JY, Tranæus A, Han DS. Effects of icodextrin on patien...

This paper presents an extension to an agent-based model of opinion dynamics built on dialogical logic DIAL. The extended model tackles a pervasive problem in argumentation logics: the difference between linguistic and logical inconsistency. Using fuzzy logic, the linear ordering of opinions, used in DIAL, is replaced by a set of partial orderings leading to a new, nonstandard notion of consist...

The response to chemical stimuli (chemical responsiveness) and the increases in respiratory drive required for arousal (arousal threshold) and for opening the airway without arousal (effective recruitment threshold) are important determinants of ventilatory instability and, hence, severity of obstructive apnea. We measured these variables in 21 obstructive apnea patients (apnea-hypopnea index 9...

The k-forest problem is a common generalization of both the k-MST and the dense-k-subgraph problems. Formally, given a metric space on n vertices V , with m demand pairs ⊆ V × V and a “target” k ≤ m, the goal is to find a minimum cost subgraph that connects at least k demand pairs. In this paper, we give an O(min{√n, √ k})-approximation algorithm for k-forest, improving on the previous best rat...